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http://doi.org/10.25358/openscience-8326
Autoren: | Paeslack, Nadja Mimmler, Maximilian Becker, Stefanie Gao, Zhenling Khuu, My Phung Mann, Amrit Malinarich, Frano Regen, Tommy Reinhardt, Christoph |
Titel: | Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease |
Online-Publikationsdatum: | 4-Jan-2023 |
Erscheinungsdatum: | 2022 |
Sprache des Dokuments: | Englisch |
Zusammenfassung/Abstract: | The essential amino acid tryptophan (Trp) is metabolized by gut commensals, yielding in compounds that affect innate immune cell functions directly, but also acting on the aryl hydrocarbon receptor (AHR), thus regulating the maintenance of group 3 innate lymphoid cells (ILCs), promoting T helper 17 (TH17) cell differentiation, and interleukin-22 production. In addition, microbiota-derived Trp metabolites have direct effects on the vascular endothelium, thus influencing the development of vascular inflammatory phenotypes. Indoxyl sulfate was demonstrated to promote vascular inflammation, whereas indole-3-propionic acid and indole-3-aldehyde had protective roles. Furthermore, there is increasing evidence for a contributory role of microbiota-derived indole-derivatives in blood pressure regulation and hypertension. Interestingly, there are indications for a role of the kynurenine pathway in atherosclerotic lesion development. Here, we provide an overview on the emerging role of gut commensals in the modulation of Trp metabolism and its influence in cardiovascular disease development. |
DDC-Sachgruppe: | 610 Medizin 610 Medical sciences |
Veröffentlichende Institution: | Johannes Gutenberg-Universität Mainz |
Organisationseinheit: | FB 04 Medizin |
Veröffentlichungsort: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-8326 |
Version: | Published version |
Publikationstyp: | Zeitschriftenaufsatz |
Nutzungsrechte: | CC BY |
Informationen zu den Nutzungsrechten: | https://creativecommons.org/licenses/by/4.0/ |
Zeitschrift: | Amino acids 54 |
Seitenzahl oder Artikelnummer: | 1339 1356 |
Verlag: | Springer |
Verlagsort: | Wien u.a. |
Erscheinungsdatum: | 2022 |
ISSN: | 1438-2199 |
DOI der Originalveröffentlichung: | 10.1007/s00726-022-03161-5 |
Enthalten in den Sammlungen: | DFG-491381577-H |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | ||
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microbiotaderived_tryptophan_-20221117144742884.pdf | 1.36 MB | Adobe PDF | Öffnen/Anzeigen |