Authors:	Hüppe, Natkritta
Title:	Multicomponent encapsulation into protein nanocarriers for co-delivery of therapeutics
Online publication date:	15-Feb-2023
Year of first publication:	2023
Language:	english
Abstract:	Successful tumor vaccination relies on a strong and durable immune response. Common soluble vaccine formulations lack the efficiency for sufficient stimulation of immune cells against tumor cells. This thesis presents the development of a multifunctional nanocarrier to enhance immune cell stimulation and tumor vaccination. The biocompatible and degradable protein nanocapsules are formed through an interfacial crosslinking via a metal-free azide-alkyne click in an inverse miniemulsion. This allows a multicomponent encapsulation of adjuvants into protein nanocapsules with high efficiency, controlled concentration and without affecting the activity of the cargo molecules. The protein nanocapsules could be functionalized on the surface with stealth and targeting moieties to enhance the specific uptake into dendritic cells.
DDC:	500 Naturwissenschaften 500 Natural sciences and mathematics 540 Chemie 540 Chemistry and allied sciences 610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch. Sonderforschungsbereiche (SFB)
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8091
URN:	urn:nbn:de:hebis:77-openscience-6c4973fe-6864-48e8-ab8b-4a5356a8da822
Version:	Original work
Publication type:	Dissertation
License:	In Copyright
Information on rights of use:	http://rightsstatements.org/vocab/InC/1.0/
Extent:	xiv, 220 Seiten
Appears in collections:	JGU-Publikationen