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Authors: Kisukuri, Camila M.
Fernandes, Vitor A.
Delgado, José A. C.
Häring, Andreas P.
Paixão, Márcio W.
Waldvogel, Siegfried R.
Title: Electrochemical installation of CFH2−, CF2H−, CF3−, and perfluoroalkyl groups into small organic molecules
Online publication date: 11-Nov-2022
Year of first publication: 2021
Language: english
Abstract: Electrosynthesis can be considered a powerful and sustainable methodology for the synthesis of small organic molecules. Due to its intrinsic ability to generate highly reactive species under mild conditions by anodic oxidation or cathodic reduction, electrosynthesis is particularly interesting for otherwise challenging transformations. One such challenge is the installation of fluorinated alkyl groups, which has gained significant attention in medicinal chemistry and material science due to their unique physicochemical features. Unsurprisingly, several electrochemical fluoroalkylation methods have been established. In this review, we survey recent developments and established methods in the field of electrochemical mono-, di-, and trifluoromethylation, and perfluoroalkylation of small organic molecules.
DDC: 540 Chemie
540 Chemistry and allied sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 09 Chemie, Pharmazie u. Geowissensch.
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC-ND
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Journal: The chemical record
Pages or article number: 2502
Publisher: Wiley-VCH
Publisher place: Weinheim
Issue date: 2021
ISSN: 1528-0691
Publisher DOI: 10.1002/tcr.202100065
Appears in collections:JGU-Publikationen

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