Gutenberg Open Science: RAFT synthesis of reactive multifunctional triblock-copolymers for polyplex formation

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8075

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DC Field	Value	Language
dc.contributor.author	Ritt, Nicolas	-
dc.contributor.author	Ayaou, Amal	-
dc.contributor.author	Zentel, Rudolf	-
dc.date.accessioned	2022-11-11T09:13:54Z	-
dc.date.available	2022-11-11T09:13:54Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8090	-
dc.description.abstract	Reversible addition–fragmentation chain transfer polymerization with a low-temperature initiator can be used to synthesize multifunctional block copolymers for polyplex formation. Utilizing three methacrylate monomers (triethylene glycol methyl ether methacrylate (MEO3MA), pyridyldisulfideethyl methacrylate (PDSM), N,N-dimethylethylenediamine methacrylate (DMAEMA)) and an azide bearing chain transfer agent for polymerization, the resulting triblock-copolymers possess two orthogonally reactive functionalities (a block with reactive disulfide side chains and an azide end-group) and two additional functional blocks for i) solubilization and ii) polyplex formation. Thereby, the MEO3MA block provides solubility in aqueous media and the DMAEMA block, having a tertiary amine in the side chain, allows polyplex formation with polyanionic biomacromolecules like DNA or RNA. Due to the reactive disulfide block the polyplexes can be (reversibly) crosslinked with dithiols. Because of the manifold of possibilities to modify the pDNApolyplexes, this polymers system is an interesting candidate for active-targeting and codelivery approaches.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	540 Chemie	de_DE
dc.subject.ddc	540 Chemistry and allied sciences	en_GB
dc.title	RAFT synthesis of reactive multifunctional triblock-copolymers for polyplex formation	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8075	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 09 Chemie, Pharmazie u. Geowissensch.	de
jgu.organisation.number	7950	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Macromolecular chemistry and physics	de
jgu.journal.volume	222	de
jgu.journal.issue	16	de
jgu.pages.alternative	2100122	de
jgu.publisher.year	2021	-
jgu.publisher.name	Wiley-VCH	de
jgu.publisher.place	Weinheim	de
jgu.publisher.issn	1521-3935	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	540	de
jgu.publisher.doi	10.1002/macp.202100122	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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