Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8048
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJackel, Sven-
dc.contributor.authorBollmann, Franziska-
dc.contributor.authorSchmidtke, Lisa-
dc.contributor.authorSchrick, Katharina-
dc.contributor.authorReinhardt, Christoph-
dc.contributor.authorJurk, Kerstin-
dc.contributor.authorWu, Zhixiong-
dc.contributor.authorXia, Ning-
dc.contributor.authorLi, Huige-
dc.contributor.authorErkel, Gerhard-
dc.contributor.authorWalter, Ulrich-
dc.contributor.authorKleinert, Hartmut-
dc.contributor.authorPautz, Andrea-
dc.date.accessioned2022-10-17T07:20:28Z-
dc.date.available2022-10-17T07:20:28Z-
dc.date.issued2015
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/8063-
dc.description.abstractPatients suffering from chronic inflammatory diseases have an increased mortality risk resulting from cardiovascular disorders due to enhanced atherosclerotic and thrombotic events. Until now, it is not completely understood in which way an abnormal expression of pro-inflammatory mediators contributes to this elevated cardiovascular risk, but there is a need for new drugs that on the one hand suppress the expression of pro-inflammatory mediators and on the other hand inhibit arterial platelet adhesion. Thus, we analyzed the anti-inflammatory and anti-thrombotic capacity of the fungal metabolite Galiellalactone in atherosclerosis-prone apolipoprotein E-deficient mice. Treatment of the mice with Galiellalactone lowered the inflammatory expression profile and improved blood clotting times, as well as platelet adhesion to the injured common carotid artery. The results indicate that administration of Galiellalactone is able to reduce the extent of inflammation and arterial platelet adhesion in this mouse model.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleAnti-inflammatory and anti-thrombotic effects of the fungal metabolite Galiellalactone in apolipoprotein E-deficient miceen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-8048-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titlePLoS onede
jgu.journal.volume10de
jgu.journal.issue6de
jgu.pages.alternativee0130401de
jgu.publisher.year2015-
jgu.publisher.namePLoSde
jgu.publisher.placeLawrence, Kan.de
jgu.publisher.urihttp://dx.doi.org/10.1371/journal.pone.0130401de
jgu.publisher.issn1932-6203de
jgu.organisation.placeMainz-
jgu.identifier.pmid26076475
jgu.subject.ddccode610de
opus.date.modified2019-01-22T10:31:49Z
opus.subject.dfgcode00-000
opus.organisation.stringFB 04: Medizin: Institut für Pharmakologiede_DE
opus.organisation.stringFB 04: Medizin: Centrum für Thrombose und Hämostase (CTH)de_DE
opus.identifier.opusid51988
opus.importsourcepubmed
opus.institute.number0413
opus.institute.number0463
opus.metadataonlyfalse
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN
opus.affiliatedReinhardt, Christoph
opus.affiliatedXia, Ning
opus.affiliatedLi, Huige
opus.affiliatedWalter, Ulrich
opus.affiliatedKleinert, Hartmut
opus.affiliatedPautz, Andrea
jgu.publisher.doi10.1371/journal.pone.0130401de
jgu.organisation.rorhttps://ror.org/023b0x485-
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

Files in This Item:
  File Description SizeFormat
Thumbnail
antiinflammatory_and_antithro-20220925164000554.pdf814.43 kBAdobe PDFView/Open