Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-8048
Authors: | Jackel, Sven Bollmann, Franziska Schmidtke, Lisa Schrick, Katharina Reinhardt, Christoph Jurk, Kerstin Wu, Zhixiong Xia, Ning Li, Huige Erkel, Gerhard Walter, Ulrich Kleinert, Hartmut Pautz, Andrea |
Title: | Anti-inflammatory and anti-thrombotic effects of the fungal metabolite Galiellalactone in apolipoprotein E-deficient mice |
Online publication date: | 17-Oct-2022 |
Year of first publication: | 2015 |
Language: | english |
Abstract: | Patients suffering from chronic inflammatory diseases have an increased mortality risk resulting from cardiovascular disorders due to enhanced atherosclerotic and thrombotic events. Until now, it is not completely understood in which way an abnormal expression of pro-inflammatory mediators contributes to this elevated cardiovascular risk, but there is a need for new drugs that on the one hand suppress the expression of pro-inflammatory mediators and on the other hand inhibit arterial platelet adhesion. Thus, we analyzed the anti-inflammatory and anti-thrombotic capacity of the fungal metabolite Galiellalactone in atherosclerosis-prone apolipoprotein E-deficient mice. Treatment of the mice with Galiellalactone lowered the inflammatory expression profile and improved blood clotting times, as well as platelet adhesion to the injured common carotid artery. The results indicate that administration of Galiellalactone is able to reduce the extent of inflammation and arterial platelet adhesion in this mouse model. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-8048 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | PLoS one 10 6 |
Pages or article number: | e0130401 |
Publisher: | PLoS |
Publisher place: | Lawrence, Kan. |
Issue date: | 2015 |
ISSN: | 1932-6203 |
Publisher URL: | http://dx.doi.org/10.1371/journal.pone.0130401 |
Publisher DOI: | 10.1371/journal.pone.0130401 |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
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