Authors:	Jackel, Sven Bollmann, Franziska Schmidtke, Lisa Schrick, Katharina Reinhardt, Christoph Jurk, Kerstin Wu, Zhixiong Xia, Ning Li, Huige Erkel, Gerhard Walter, Ulrich Kleinert, Hartmut Pautz, Andrea
Title:	Anti-inflammatory and anti-thrombotic effects of the fungal metabolite Galiellalactone in apolipoprotein E-deficient mice
Online publication date:	17-Oct-2022
Year of first publication:	2015
Language:	english
Abstract:	Patients suffering from chronic inflammatory diseases have an increased mortality risk resulting from cardiovascular disorders due to enhanced atherosclerotic and thrombotic events. Until now, it is not completely understood in which way an abnormal expression of pro-inflammatory mediators contributes to this elevated cardiovascular risk, but there is a need for new drugs that on the one hand suppress the expression of pro-inflammatory mediators and on the other hand inhibit arterial platelet adhesion. Thus, we analyzed the anti-inflammatory and anti-thrombotic capacity of the fungal metabolite Galiellalactone in atherosclerosis-prone apolipoprotein E-deficient mice. Treatment of the mice with Galiellalactone lowered the inflammatory expression profile and improved blood clotting times, as well as platelet adhesion to the injured common carotid artery. The results indicate that administration of Galiellalactone is able to reduce the extent of inflammation and arterial platelet adhesion in this mouse model.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8048
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	PLoS one 10 6
Pages or article number:	e0130401
Publisher:	PLoS
Publisher place:	Lawrence, Kan.
Issue date:	2015
ISSN:	1932-6203
Publisher URL:	http://dx.doi.org/10.1371/journal.pone.0130401
Publisher DOI:	10.1371/journal.pone.0130401
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)