Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8045
Authors: Gussmann, Kathrin
Kirschnek, Susanne
Loewenich, Friederike von
Title: Interferon-γ-dependent control of Anaplasma phagocytophilum by murine neutrophil granulocytes
Online publication date: 17-Oct-2022
Year of first publication: 2017
Language: english
Abstract: Anaplasma phagocytophilum is a Gram-negative obligate intracellular bacterium that is transmitted by ticks of the Ixodes ricinus complex. It replicates in neutrophils and elicits febrile disease in humans and animals. Because of its striking tropism for neutrophils, A. phagocytophilum has been used as a model organism to study the immune response against obligate intracellular pathogens. In mice, the control of A. phagocytophilum in the early phase of infection is dependent on natural killer cell-derived interferon-γ (IFN-γ). In contrast, the final elimination strictly requires CD4+ T-cells. It is a matter of debate, whether neutrophils serve only as host cells or as killer cells as well.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-8045
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
Information on rights of use: https://creativecommons.org/licenses/by/4.0/
Journal: Parasites & vectors
10
Pages or article number: Art. 329
Publisher: BioMed Central
Publisher place: London
Issue date: 2017
ISSN: 1756-3305
Publisher URL: http://dx.doi.org/10.1186/s13071-017-2274-6
Publisher DOI: 10.1186/s13071-017-2274-6
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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