Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-8045
Authors: | Gussmann, Kathrin Kirschnek, Susanne Loewenich, Friederike von |
Title: | Interferon-γ-dependent control of Anaplasma phagocytophilum by murine neutrophil granulocytes |
Online publication date: | 17-Oct-2022 |
Year of first publication: | 2017 |
Language: | english |
Abstract: | Anaplasma phagocytophilum is a Gram-negative obligate intracellular bacterium that is transmitted by ticks of the Ixodes ricinus complex. It replicates in neutrophils and elicits febrile disease in humans and animals. Because of its striking tropism for neutrophils, A. phagocytophilum has been used as a model organism to study the immune response against obligate intracellular pathogens. In mice, the control of A. phagocytophilum in the early phase of infection is dependent on natural killer cell-derived interferon-γ (IFN-γ). In contrast, the final elimination strictly requires CD4+ T-cells. It is a matter of debate, whether neutrophils serve only as host cells or as killer cells as well. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-8045 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Parasites & vectors 10 |
Pages or article number: | Art. 329 |
Publisher: | BioMed Central |
Publisher place: | London |
Issue date: | 2017 |
ISSN: | 1756-3305 |
Publisher URL: | http://dx.doi.org/10.1186/s13071-017-2274-6 |
Publisher DOI: | 10.1186/s13071-017-2274-6 |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
Files in This Item:
File | Description | Size | Format | ||
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interferondependent_control_o-20220925163610337.pdf | 1.41 MB | Adobe PDF | View/Open |