Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-800
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dc.contributor.authorEppard, Elisabeth-
dc.contributor.authorFuente, Ana de la-
dc.contributor.authorMohr, Nicole-
dc.contributor.authorAllmeroth, Mareli-
dc.contributor.authorZentel, Rudolf-
dc.contributor.authorMiederer, Matthias-
dc.contributor.authorPektor, Stefanie-
dc.contributor.authorRösch, Frank-
dc.date.accessioned2018-08-02T09:48:35Z-
dc.date.available2018-08-02T11:48:35Z-
dc.date.issued2018-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/802-
dc.description.abstractBackground In this work, the in vitro and in vivo stabilities and the pharmacology of HPMA-made homopolymers were studied by means of radiometal-labeled derivatives. Aiming to identify the fewer amount and the optimal DOTA-linker structure that provides quantitative labeling yields, diverse DOTA-linker systems were conjugated in different amounts to HPMA homopolymers to coordinate trivalent radiometals Me(III)* = gallium-68, scandium-44, and lutetium-177. Results Short linkers and as low as 1.6% DOTA were enough to obtain labeling yields > 90%. Alkoxy linkers generally exhibited lower labeling yields than alkane analogues despite of similar chain length and DOTA incorporation rate. High stability of the radiolabel in all examined solutions was observed for all conjugates. Labeling with scandium-44 allowed for in vivo PET imaging and ex vivo measurements of organ distribution for up to 24 h. Conclusions This study confirms the principle applicability of DOTA-HPMA conjugates for labeling with different trivalent metallic radionuclides allowing for diagnosis and therapy.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin-
dc.language.isoeng-
dc.rightsCC-BYde_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleLabeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imagingen_GB
dc.typeZeitschriftenaufsatzde_DE
dc.identifier.urnurn:nbn:de:hebis:77-publ-584092-
dc.identifier.doihttp://doi.org/10.25358/openscience-800-
jgu.type.dinitypearticle-
jgu.type.versionPublished versionen_GB
jgu.type.resourceText-
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.-
jgu.organisation.departmentFB 04 Medizin-
jgu.organisation.number7950-
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleEJNMMI Research-
jgu.journal.volume8-
jgu.pages.alternativeArt. 16-
jgu.publisher.year2018-
jgu.publisher.nameSpringer-
jgu.publisher.placeBerlin-
jgu.publisher.urihttp://dx.doi.org/10.1186/s13550-018-0372-x-
jgu.publisher.issn2191-219X-
jgu.organisation.placeMainz-
jgu.subject.ddccode610-
opus.date.accessioned2018-08-02T09:48:35Z-
opus.date.modified2018-08-06T09:46:35Z-
opus.date.available2018-08-02T11:48:35-
opus.subject.dfgcode00-000-
opus.organisation.stringFB 04: Medizin: Klinik und Poliklinik für Nuklearmedizinde_DE
opus.organisation.stringFB 09: Chemie, Pharmazie und Geowissenschaften: Institut für Kernchemiede_DE
opus.organisation.stringFB 09: Chemie, Pharmazie und Geowissenschaften: Institut für Organische Chemiede_DE
opus.identifier.opusid58409-
opus.institute.number0422-
opus.institute.number0904-
opus.institute.number0905-
opus.metadataonlyfalse-
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_GB
opus.affiliatedZentel, Rudolf-
opus.affiliatedMiederer, Matthias-
opus.affiliatedPektor, Stefanie-
opus.affiliatedRösch, Frank-
Appears in collections:JGU-Publikationen

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