Simulation of complex data structures for planning of studies with focus on biomarker comparison
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There are a growing number of observational studies that do not only focus on single biomarkers for predicting an outcome event, but address questions in a multivariable setting. For example, when quantifying the added value of new biomarkers in addition to established risk factors, the aim might be to rank several new markers with respect to their prediction performance. This makes it important to consider the marker correlation structure for planning such a study. Because of the complexity, a simulation approach may be required to adequately assess sample size or other aspects, such as the choice of a performance measure.
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BMC medical research methodology, 17, BioMed Central, London, 2017, https://doi.org/10.1186/s12874-017-0364-y