Simulation of complex data structures for planning of studies with focus on biomarker comparison

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dc.contributor.authorSchulz, Andreas
dc.contributor.authorZöller, Daniela
dc.contributor.authorNickels, Stefan
dc.contributor.authorBeutel, Manfred E.
dc.contributor.authorBlettner, Maria
dc.contributor.authorWild, Philipp
dc.contributor.authorBinder, Harald
dc.date.accessioned2022-10-14T07:22:18Z
dc.date.available2022-10-14T07:22:18Z
dc.date.issued2017
dc.description.abstractThere are a growing number of observational studies that do not only focus on single biomarkers for predicting an outcome event, but address questions in a multivariable setting. For example, when quantifying the added value of new biomarkers in addition to established risk factors, the aim might be to rank several new markers with respect to their prediction performance. This makes it important to consider the marker correlation structure for planning such a study. Because of the complexity, a simulation approach may be required to adequately assess sample size or other aspects, such as the choice of a performance measure.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.identifier.doihttp://doi.org/10.25358/openscience-8001
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/8016
dc.language.isoengde
dc.rightsCC-BY-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleSimulation of complex data structures for planning of studies with focus on biomarker comparisonen_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.titleBMC medical research methodologyde
jgu.journal.volume17de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternativeArt. 90de
jgu.publisher.doi10.1186/s12874-017-0364-yde
jgu.publisher.issn1471-2288de
jgu.publisher.nameBioMed Centralde
jgu.publisher.placeLondonde
jgu.publisher.urihttp://dx.doi.org/10.1186/s12874-017-0364-yde
jgu.publisher.year2017
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde
opus.affiliatedNickels, Stefan
opus.affiliatedBeutel, Manfred E.
opus.affiliatedBlettner, Maria
opus.affiliatedWild, Philipp
opus.affiliatedBinder, Harald
opus.date.modified2019-11-14T11:22:03Z
opus.identifier.opusid58000
opus.institute.number0424
opus.institute.number0426
opus.institute.number0434
opus.metadataonlyfalse
opus.organisation.stringFB 04: Medizin: Institut für Med. Biometrie, Epidemologie und Informatikde_DE
opus.organisation.stringFB 04: Medizin: II. Medizinische Klinik und Poliklinikde_DE
opus.organisation.stringFB 04: Medizin: Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapiede_DE
opus.subject.dfgcode00-000
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN

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