Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-798Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Weckmann, Katja | - |
| dc.contributor.author | Diefenthäler, Philip | - |
| dc.contributor.author | Baeken, Marius W. | - |
| dc.contributor.author | Yusifli, Kamran | - |
| dc.contributor.author | Turck, Christoph W. | - |
| dc.contributor.author | Asara, John M. | - |
| dc.contributor.author | Behl, Christian | - |
| dc.contributor.author | Hajieva, Parvana | - |
| dc.date.accessioned | 2018-08-02T09:15:57Z | - |
| dc.date.available | 2018-08-02T11:15:57Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/800 | - |
| dc.description.abstract | The ability of cells to rearrange their metabolism plays an important role in compensating the energy shortage and may provide cell survival. Our study focuses on identifing the important adaptational changes under the conditions of oxygen and glucose reduction. Employing mass spectrometry-based metabolomics in combination with biochemistry and microscopy techniques we identified metabolites, proteins and biomolecular pathways alterations in primary human IMR90 fibroblasts upon energy deficits. Multivariate statistical analyses revealed significant treatment specific metabolite level and ratio alterations as well as major energy metabolism pathways like ‘glycolysis’, ‘pentose phosphate pathway’, ‘mitochondrial electron transport chain’ and ‘protein biosynthesis (amino acids)’ indicating an activation of catabolism and reduction of anabolism as important mechanisms of adaptation towards a bioenergetic demand. A treatment-specific induction of the autophagic and mitophagic degradation activity upon oxygen reduction, glucose reduction as well as oxygen-glucose reduction further supports our results. Therefore, we suggest that the observed alterations represent an adaptive response in order to compensate for the cells’ bioenergetics needs that ultimately provide cell survival. | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | - |
| dc.language.iso | eng | - |
| dc.rights | CC BY | de_DE |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction | en_GB |
| dc.type | Zeitschriftenaufsatz | de_DE |
| dc.identifier.urn | urn:nbn:de:hebis:77-publ-584072 | - |
| dc.identifier.doi | http://doi.org/10.25358/openscience-798 | - |
| jgu.type.dinitype | article | - |
| jgu.type.version | Published version | en_GB |
| jgu.type.resource | Text | - |
| jgu.organisation.department | FB 04 Medizin | - |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Scientific reports | - |
| jgu.journal.volume | 8 | - |
| jgu.pages.alternative | Art. 2337 | - |
| jgu.publisher.year | 2018 | - |
| jgu.publisher.name | Macmillan Publishers Limited, part of Springer Nature | - |
| jgu.publisher.place | London | - |
| jgu.publisher.uri | http://dx.doi.org/10.1038/s41598-018-19421-y | - |
| jgu.publisher.issn | 2045-2322 | - |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | - |
| opus.date.accessioned | 2018-08-02T09:15:57Z | - |
| opus.date.modified | 2018-08-13T07:40:10Z | - |
| opus.date.available | 2018-08-02T11:15:57 | - |
| opus.subject.dfgcode | 00-000 | - |
| opus.organisation.string | FB 04: Medizin: Institut für Pathobiochemie | de_DE |
| opus.identifier.opusid | 58407 | - |
| opus.institute.number | 0473 | - |
| opus.metadataonly | false | - |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_GB |
| opus.affiliated | Weckmann, Katja | - |
| opus.affiliated | Behl, Christian | - |
| opus.affiliated | Hajieva, Parvana | - |
| jgu.publisher.doi | 10.1038/s41598-018-19421-y | - |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| Appears in collections: | JGU-Publikationen | |
