Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7972
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dc.contributor.authorTeodorczyk, Marcin-
dc.contributor.authorSchmidt, Mirko HH-
dc.date.accessioned2022-10-13T07:56:25Z-
dc.date.available2022-10-13T07:56:25Z-
dc.date.issued2015
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7987-
dc.description.abstractNotch receptors play an essential role in the regulation of central cellular processes during embryonic and postnatal development. The mammalian genome encodes for four Notch paralogs (Notch 1–4), which are activated by three Delta-like (Dll1/3/4) and two Serrate-like (Jagged1/2) ligands. Further, non-canonical Notch ligands such as epidermal growth factor like protein 7 (EGFL7) have been identified and serve mostly as antagonists of Notch signaling. The Notch pathway prevents neuronal differentiation in the central nervous system by driving neural stem cell maintenance and commitment of neural progenitor cells into the glial lineage. Notch is therefore often implicated in the development of brain tumors, as tumor cells share various characteristics with neural stem and progenitor cells. Notch receptors are overexpressed in gliomas and their oncogenicity has been confirmed by gain- and loss-of-function studies in vitro and in vivo. To this end, special attention is paid to the impact of Notch signaling on stem-like brain tumor-propagating cells as these cells contribute to growth, survival, invasion, and recurrence of brain tumors. Based on the outcome of ongoing studies in vivo, Notch-directed therapies such as γ-secretase inhibitors and blocking antibodies have entered and completed various clinical trials. This review summarizes the current knowledge on Notch signaling in brain tumor formation and therapy.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleNotching on cancer’s door : Notch signaling in brain tumorsen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-7972-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleFrontiers in oncologyde
jgu.journal.volume4de
jgu.pages.alternativeArt. 341de
jgu.publisher.year2015-
jgu.publisher.nameFrontiers Mediade
jgu.publisher.placeLausannede
jgu.publisher.urihttp://dx.doi.org/10.3389/fonc.2014.00341de
jgu.publisher.issn2234-943Xde
jgu.organisation.placeMainz-
jgu.identifier.pmid25601901
jgu.subject.ddccode610de
opus.date.modified2018-09-05T09:12:59Z
opus.subject.dfgcode00-000
opus.organisation.stringFB 04: Medizin: Institut für Mikroskopische Anatomie und Neurobiologiede_DE
opus.identifier.opusid51970
opus.importsourcepubmed
opus.institute.number0459
opus.metadataonlyfalse
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN
opus.affiliatedSchmidt, Mirko HH
jgu.publisher.doi10.3389/fonc.2014.00341de
jgu.organisation.rorhttps://ror.org/023b0x485-
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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