Gutenberg Open Science: SncRNA715 inhibits Schwann cell myelin basic protein synthesis

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7964

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DC Field	Value	Language
dc.contributor.author	Müller, Christina	-
dc.contributor.author	Hochhaus, Nina	-
dc.contributor.author	Fontana, Xavier	-
dc.contributor.author	Luhmann, Heiko	-
dc.contributor.author	White, Robin	-
dc.date.accessioned	2022-10-13T07:12:31Z	-
dc.date.available	2022-10-13T07:12:31Z	-
dc.date.issued	2015
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7979	-
dc.description.abstract	Myelin basic proteins (MBP) are major constituents of the myelin sheath in the central nervous system (CNS) and the peripheral nervous system (PNS). In the CNS Mbp translation occurs locally at the axon-glial contact site in a neuronal activity-dependent manner. Recently we identified the small non-coding RNA 715 (sncRNA715) as a key inhibitor of Mbp translation during transport in oligodendrocytes. Mbp mRNA localization in Schwann cells has been observed, but has not been investigated in much detail. Here we could confirm translational repression of Mbp mRNA in Schwann cells. We show that sncRNA715 is expressed and its levels correlate inversely with MBP in cultured Schwann cells and in the sciatic nerve in vivo. Furthermore we could reduce MBP protein levels in cultured Schwann cells by increasing the levels of the inhibitory sncRNA715. Our findings suggest similarities in sncRNA715-mediated translational repression of Mbp mRNA in oligodendrocytes and Schwann cells.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	SncRNA715 inhibits Schwann cell myelin basic protein synthesis	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7964	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	PLoS one	de
jgu.journal.volume	10	de
jgu.journal.issue	8	de
jgu.pages.alternative	e0136900	de
jgu.publisher.year	2015	-
jgu.publisher.name	PLoS	de
jgu.publisher.place	Lawrence, Kan.	de
jgu.publisher.uri	http://dx.doi.org/10.1371/journal.pone.0136900	de
jgu.publisher.issn	1932-6203	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-09-05T09:19:39Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Institut für Physiologie und Pathophysiologie	de_DE
opus.identifier.opusid	56515
opus.institute.number	0403
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Hochhaus, Nina
opus.affiliated	Luhmann, Heiko
opus.affiliated	White, Robin
jgu.publisher.doi	10.1371/journal.pone.0136900	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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