Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7964
Authors: | Müller, Christina Hochhaus, Nina Fontana, Xavier Luhmann, Heiko White, Robin |
Title: | SncRNA715 inhibits Schwann cell myelin basic protein synthesis |
Online publication date: | 13-Oct-2022 |
Year of first publication: | 2015 |
Language: | english |
Abstract: | Myelin basic proteins (MBP) are major constituents of the myelin sheath in the central nervous system (CNS) and the peripheral nervous system (PNS). In the CNS Mbp translation occurs locally at the axon-glial contact site in a neuronal activity-dependent manner. Recently we identified the small non-coding RNA 715 (sncRNA715) as a key inhibitor of Mbp translation during transport in oligodendrocytes. Mbp mRNA localization in Schwann cells has been observed, but has not been investigated in much detail. Here we could confirm translational repression of Mbp mRNA in Schwann cells. We show that sncRNA715 is expressed and its levels correlate inversely with MBP in cultured Schwann cells and in the sciatic nerve in vivo. Furthermore we could reduce MBP protein levels in cultured Schwann cells by increasing the levels of the inhibitory sncRNA715. Our findings suggest similarities in sncRNA715-mediated translational repression of Mbp mRNA in oligodendrocytes and Schwann cells. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7964 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | PLoS one 10 8 |
Pages or article number: | e0136900 |
Publisher: | PLoS |
Publisher place: | Lawrence, Kan. |
Issue date: | 2015 |
ISSN: | 1932-6203 |
Publisher URL: | http://dx.doi.org/10.1371/journal.pone.0136900 |
Publisher DOI: | 10.1371/journal.pone.0136900 |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
Files in This Item:
File | Description | Size | Format | ||
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![]() | sncrna715_inhibits_schwann_ce-20220925143755600.pdf | 1.18 MB | Adobe PDF | View/Open |