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Authors: Müller, Christina
Hochhaus, Nina
Fontana, Xavier
Luhmann, Heiko
White, Robin
Title: SncRNA715 inhibits Schwann cell myelin basic protein synthesis
Online publication date: 13-Oct-2022
Year of first publication: 2015
Language: english
Abstract: Myelin basic proteins (MBP) are major constituents of the myelin sheath in the central nervous system (CNS) and the peripheral nervous system (PNS). In the CNS Mbp translation occurs locally at the axon-glial contact site in a neuronal activity-dependent manner. Recently we identified the small non-coding RNA 715 (sncRNA715) as a key inhibitor of Mbp translation during transport in oligodendrocytes. Mbp mRNA localization in Schwann cells has been observed, but has not been investigated in much detail. Here we could confirm translational repression of Mbp mRNA in Schwann cells. We show that sncRNA715 is expressed and its levels correlate inversely with MBP in cultured Schwann cells and in the sciatic nerve in vivo. Furthermore we could reduce MBP protein levels in cultured Schwann cells by increasing the levels of the inhibitory sncRNA715. Our findings suggest similarities in sncRNA715-mediated translational repression of Mbp mRNA in oligodendrocytes and Schwann cells.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: PLoS one
Pages or article number: e0136900
Publisher: PLoS
Publisher place: Lawrence, Kan.
Issue date: 2015
ISSN: 1932-6203
Publisher URL:
Publisher DOI: 10.1371/journal.pone.0136900
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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