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Authors: Walter, Christian
Ziebart, Thomas
Sagheb, Keyvan
Rahimi-Nedjat, Roman Kia
Manz, Asina
Hess, Georg
Title: Malignant lymphomas in the head and neck region : a retrospective, single-center study over 41 years
Online publication date: 6-Oct-2022
Year of first publication: 2015
Language: english
Abstract: OBJECTIVES: Non-Hodgkin lymphomas are malignant neoplastic proliferations of the immune system that can manifest as nodal or extranodal lymphomas. The aim of this study was to retrospectively investigate the site of occurrence of lymphomas in the head and neck area and to analyze the typical symptoms of patients who presented at an oral and maxillofacial surgical department. MATERIAL AND METHODS: All patient files from 1971 until 2012 from an Oral and Maxillofacial Surgery of a University were analyzed for the diagnosis non-Hodgkin lymphoma. Epidemiologic data and data regarding the localization of the malignant lymphoma were evaluated. RESULTS: 62 patients, 34 women and 28 men with a non-Hodgkin lymphoma in the head and neck area were treated in the 41 years analyzed. In 87% of the cases the lymphoma belonged to B-cell and in 12% to the T-cell lineage. The average age at the time of diagnosis was 67 years for women (n=34) and 56 years for men. With 22 patients each, the non-Hodgkin lymphoma was localized in either the soft tissues or osseous structures. In the remaining 18 cases, multiple structures were affected. In 33 patients no accompanying nodal manifestation was noticed. In 33 cases the lymphoma was located in the oral cavity. The most common symptoms were swelling (97%), pain (40%) and the existence of an ulcer (11%). CONCLUSION: In the present study more than 50% of the lymphomas were located in the oral cavity. Due to the unspecific symptoms, a histopathological verification of the diagnosis is crucial.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC-ND
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Journal: International journal of medical sciences
Pages or article number: 141
Publisher: Ivyspring International Publ.
Publisher place: Wyoming, NSW
Issue date: 2015
ISSN: 1449-1907
Publisher URL:
Publisher DOI: 10.7150/ijms.10483
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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