Gutenberg Open Science: The importance of thrombin in cerebral injury and disease

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7888

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DC Field	Value	Language
dc.contributor.author	Krenzlin, Harald	-
dc.contributor.author	Lorenz, Viola	-
dc.contributor.author	Danckwardt, Sven	-
dc.contributor.author	Kempski, Oliver	-
dc.contributor.author	Alessandri, Beat	-
dc.date.accessioned	2022-10-06T07:58:31Z	-
dc.date.available	2022-10-06T07:58:31Z	-
dc.date.issued	2016
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7903	-
dc.description.abstract	There is increasing evidence that prothrombin and its active derivative thrombin are expressed locally in the central nervous system. so far, little is known about the physiological and pathophysiological functions exerted by thrombin in the human brain. extra-hepatic prothrombin expression has been identified in neuronal cells and astrocytes via mrna measurement. the actual amount of brain derived prothrombin is expected to be 1% or less compared to that in the liver. the role in brain injury depends upon its concentration, as higher amounts cause neuroinflammation and apoptosis, while lower concentrations might even be cytoprotective. its involvement in numerous diseases like alzheimer’s, multiple sclerosis, cerebral ischemia and haemorrhage is becoming increasingly clear. this review focuses on elucidation of the cerebral thrombin expression, local generation and its role in injury and disease of the central nervous system.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	The importance of thrombin in cerebral injury and disease	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7888	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	International journal of molecular sciences	de
jgu.journal.volume	17	de
jgu.journal.issue	1	de
jgu.pages.alternative	Art. 84	de
jgu.publisher.year	2016	-
jgu.publisher.name	Molecular Diversity Preservation International	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	http://dx.doi.org/10.3390/ijms17010084	de
jgu.publisher.issn	1422-0067	de
jgu.publisher.issn	1661-6596	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2019-03-13T11:11:14Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Institut für Neurochirurgische Pathophysiologie	de_DE
opus.identifier.opusid	56387
opus.institute.number	0442
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Danckwardt, Sven
opus.affiliated	Kempski, Oliver
opus.affiliated	Alessandri, Beat
jgu.publisher.doi	10.3390/ijms17010084	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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