Authors:	Krenzlin, Harald Lorenz, Viola Danckwardt, Sven Kempski, Oliver Alessandri, Beat
Title:	The importance of thrombin in cerebral injury and disease
Online publication date:	6-Oct-2022
Year of first publication:	2016
Language:	english
Abstract:	There is increasing evidence that prothrombin and its active derivative thrombin are expressed locally in the central nervous system. so far, little is known about the physiological and pathophysiological functions exerted by thrombin in the human brain. extra-hepatic prothrombin expression has been identified in neuronal cells and astrocytes via mrna measurement. the actual amount of brain derived prothrombin is expected to be 1% or less compared to that in the liver. the role in brain injury depends upon its concentration, as higher amounts cause neuroinflammation and apoptosis, while lower concentrations might even be cytoprotective. its involvement in numerous diseases like alzheimer’s, multiple sclerosis, cerebral ischemia and haemorrhage is becoming increasingly clear. this review focuses on elucidation of the cerebral thrombin expression, local generation and its role in injury and disease of the central nervous system.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7888
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	International journal of molecular sciences 17 1
Pages or article number:	Art. 84
Publisher:	Molecular Diversity Preservation International
Publisher place:	Basel
Issue date:	2016
ISSN:	1422-0067 1661-6596
Publisher URL:	http://dx.doi.org/10.3390/ijms17010084
Publisher DOI:	10.3390/ijms17010084
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)