Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7888
Authors: | Krenzlin, Harald Lorenz, Viola Danckwardt, Sven Kempski, Oliver Alessandri, Beat |
Title: | The importance of thrombin in cerebral injury and disease |
Online publication date: | 6-Oct-2022 |
Year of first publication: | 2016 |
Language: | english |
Abstract: | There is increasing evidence that prothrombin and its active derivative thrombin are expressed locally in the central nervous system. so far, little is known about the physiological and pathophysiological functions exerted by thrombin in the human brain. extra-hepatic prothrombin expression has been identified in neuronal cells and astrocytes via mrna measurement. the actual amount of brain derived prothrombin is expected to be 1% or less compared to that in the liver. the role in brain injury depends upon its concentration, as higher amounts cause neuroinflammation and apoptosis, while lower concentrations might even be cytoprotective. its involvement in numerous diseases like alzheimer’s, multiple sclerosis, cerebral ischemia and haemorrhage is becoming increasingly clear. this review focuses on elucidation of the cerebral thrombin expression, local generation and its role in injury and disease of the central nervous system. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7888 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | International journal of molecular sciences 17 1 |
Pages or article number: | Art. 84 |
Publisher: | Molecular Diversity Preservation International |
Publisher place: | Basel |
Issue date: | 2016 |
ISSN: | 1422-0067 1661-6596 |
Publisher URL: | http://dx.doi.org/10.3390/ijms17010084 |
Publisher DOI: | 10.3390/ijms17010084 |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
Files in This Item:
File | Description | Size | Format | ||
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![]() | the_importance_of_thrombin_in-20220924202643921.pdf | 1.49 MB | Adobe PDF | View/Open |