Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7883
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dc.contributor.authorGonsior, Constantin-
dc.contributor.authorBinamé, Fabien-
dc.contributor.authorFrühbeis, Carsten-
dc.contributor.authorBauer, Nina M.-
dc.contributor.authorHoch-Kraft, Peter-
dc.contributor.authorLuhmann, Heiko-
dc.contributor.authorTrotter, Jacqueline-
dc.contributor.authorWhite, Robin-
dc.date.accessioned2022-10-06T07:46:35Z-
dc.date.available2022-10-06T07:46:35Z-
dc.date.issued2014
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7898-
dc.description.abstractOligodendrocytes are the myelinating glial cells of the central nervous system. In the course of brain development, oligodendrocyte precursor cells migrate, scan the environment and differentiate into mature oligodendrocytes with multiple cellular processes which recognize and ensheath neuronal axons. During differentiation, oligodendrocytes undergo dramatic morphological changes requiring cytoskeletal rearrangements which need to be tightly regulated. The non-receptor tyrosine kinase Fyn plays a central role in oligodendrocyte differentiation and myelination. In order to improve our understanding of the role of oligodendroglial Fyn kinase, we have identified Fyn targets in these cells. Purification and mass-spectrometric analysis of tyrosine-phosphorylated proteins in response to overexpressed active Fyn in the oligodendrocyte precursor cell line Oli-neu, yielded the adaptor molecule p130Cas. We analyzed the function of this Fyn target in oligodendroglial cells and observed that reduction of p130Cas levels by siRNA affects process outgrowth, the thickness of cellular processes and migration behavior of Oli-neu cells. Furthermore, long term p130Cas reduction results in decreased cell numbers as a result of increased apoptosis in cultured primary oligodendrocytes. Our data contribute to understanding the molecular events taking place during oligodendrocyte migration and morphological differentiation and have implications for myelin formation.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleOligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survivalen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-7883-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.departmentFB 10 Biologiede
jgu.organisation.number2700-
jgu.organisation.number7970-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titlePLoS onede
jgu.journal.volume9de
jgu.journal.issue2de
jgu.pages.alternativee89423de
jgu.publisher.year2014-
jgu.publisher.namePLoSde
jgu.publisher.placeLawrence, Kan.de
jgu.publisher.urihttp://dx.doi.org/10.1371/journal.pone.0089423de
jgu.publisher.issn1932-6203de
jgu.organisation.placeMainz-
jgu.identifier.pmid24586768
jgu.subject.ddccode610de
opus.date.modified2018-08-08T08:49:19Z
opus.subject.dfgcode00-000
opus.organisation.stringFB 04: Medizin: Institut für Physiologie und Pathophysiologiede_DE
opus.organisation.stringFB 10: Biologie: Abteilung Molekulare Zellbiologie / Biologie für Medizinerde_DE
opus.identifier.opusid27342
opus.importsourcepubmed
opus.institute.number0403
opus.institute.number1004
opus.metadataonlyfalse
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN
opus.affiliatedFrühbeis, Carsten
opus.affiliatedLuhmann, Heiko
opus.affiliatedTrotter, Jacqueline
opus.affiliatedWhite, Robin
jgu.publisher.doi10.1371/journal.pone.0089423de
jgu.organisation.rorhttps://ror.org/023b0x485-
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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