Gutenberg Open Science: The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7876

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DC Field	Value	Language
dc.contributor.author	Ding, Rouven	-
dc.contributor.author	Weynans, Kevin	-
dc.contributor.author	Bossing, Torsten	-
dc.contributor.author	Barros, Claudia S.	-
dc.contributor.author	Berger, Christian	-
dc.date.accessioned	2022-10-06T07:33:22Z	-
dc.date.available	2022-10-06T07:33:22Z	-
dc.date.issued	2016
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7891	-
dc.description.abstract	Stem cells control their mitotic activity to decide whether to proliferate or to stay in quiescence. Drosophila neural stem cells (NSCs) are quiescent at early larval stages, when they are reactivated in response to metabolic changes. Here we report that cell-contact inhibition of growth through the canonical Hippo signalling pathway maintains NSC quiescence. Loss of the core kinases hippo or warts leads to premature nuclear localization of the transcriptional co-activator Yorkie and initiation of growth and proliferation in NSCs. Yorkie is necessary and sufficient for NSC reactivation, growth and proliferation. The Hippo pathway activity is modulated via inter-cellular transmembrane proteins Crumbs and Echinoid that are both expressed in a nutrient-dependent way in niche glial cells and NSCs. Loss of crumbs or echinoid in the niche only is sufficient to reactivate NSCs. Finally, we provide evidence that the Hippo pathway activity discriminates quiescent from non-quiescent NSCs in the Drosophila nervous system.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7876	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Nature communications	de
jgu.journal.volume	7	de
jgu.pages.alternative	Art. 10510	de
jgu.publisher.year	2016	-
jgu.publisher.name	Nature Publishing Group	de
jgu.publisher.place	London	de
jgu.publisher.uri	http://dx.doi.org/10.1038/ncomms10510	de
jgu.publisher.issn	2041-1723	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
opus.date.modified	2018-08-22T09:57:49Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 10: Biologie: Institut für Genetik	de_DE
opus.identifier.opusid	53813
opus.institute.number	1005
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Berger, Christian
jgu.publisher.doi	10.1038/ncomms10510	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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