Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7876
Authors: | Ding, Rouven Weynans, Kevin Bossing, Torsten Barros, Claudia S. Berger, Christian |
Title: | The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells |
Online publication date: | 6-Oct-2022 |
Year of first publication: | 2016 |
Language: | english |
Abstract: | Stem cells control their mitotic activity to decide whether to proliferate or to stay in quiescence. Drosophila neural stem cells (NSCs) are quiescent at early larval stages, when they are reactivated in response to metabolic changes. Here we report that cell-contact inhibition of growth through the canonical Hippo signalling pathway maintains NSC quiescence. Loss of the core kinases hippo or warts leads to premature nuclear localization of the transcriptional co-activator Yorkie and initiation of growth and proliferation in NSCs. Yorkie is necessary and sufficient for NSC reactivation, growth and proliferation. The Hippo pathway activity is modulated via inter-cellular transmembrane proteins Crumbs and Echinoid that are both expressed in a nutrient-dependent way in niche glial cells and NSCs. Loss of crumbs or echinoid in the niche only is sufficient to reactivate NSCs. Finally, we provide evidence that the Hippo pathway activity discriminates quiescent from non-quiescent NSCs in the Drosophila nervous system. |
DDC: | 570 Biowissenschaften 570 Life sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 10 Biologie |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7876 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Nature communications 7 |
Pages or article number: | Art. 10510 |
Publisher: | Nature Publishing Group |
Publisher place: | London |
Issue date: | 2016 |
ISSN: | 2041-1723 |
Publisher URL: | http://dx.doi.org/10.1038/ncomms10510 |
Publisher DOI: | 10.1038/ncomms10510 |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
Files in This Item:
File | Description | Size | Format | ||
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![]() | the_hippo_signalling_pathway_-20220915065814544.pdf | 3.14 MB | Adobe PDF | View/Open |