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  2. Johannes Gutenberg-Universität Mainz
  3. DFG-OA-Publizieren (2012 - 2017)
Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7868
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dc.contributor.authorHalbroth, Benedict R.-
dc.contributor.authorHeil, Alexander-
dc.contributor.authorDistler, Eva-
dc.contributor.authorDass, Martin-
dc.contributor.authorWagner, Eva Maria-
dc.contributor.authorPlachter, Bodo-
dc.contributor.authorProbst, Hans Christian-
dc.contributor.authorStrand, Dennis-
dc.contributor.authorHartwig, Udo-
dc.contributor.authorKarner, Anita-
dc.contributor.authorAichinger, Gerald-
dc.contributor.authorKistner, Otfried-
dc.contributor.authorLandfester, Katharina-
dc.contributor.authorHerr, Wolfgang-
dc.date.accessioned2022-10-06T07:14:16Z-
dc.date.available2022-10-06T07:14:16Z-
dc.date.issued2014
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7883-
dc.description.abstractPandemic and seasonal influenza viruses cause considerable morbidity and mortality in the general human population. Protection from severe disease may result from vaccines that activate antigen-presenting DC for effective stimulation of influenza-specific memory T cells. Special attention is paid to vaccine-induced CD8+ T-cell responses, because they are mainly directed against conserved internal influenza proteins thereby presumably mediating cross-protection against circulating seasonal as well as emerging pandemic virus strains. Our study showed that influenza whole virus vaccines of major seasonal A and B strains activated DC more efficiently than those of pandemic swine-origin H1N1 and pandemic-like avian H5N1 strains. In contrast, influenza split virus vaccines had a low ability to activate DC, regardless which strain was investigated. We also observed that whole virus vaccines stimulated virus-specific CD8+ memory T cells much stronger compared to split virus counterparts, whereas both vaccine formats activated CD4+ Th cell responses similarly. Moreover, our data showed that whole virus vaccine material is delivered into the cytosolic pathway of DC for effective activation of virus-specific CD8+ T cells. We conclude that vaccines against seasonal and pandemic (-like) influenza strains that aim to stimulate cross-reacting CD8+ T cells should include whole virus rather than split virus formulations.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleSuperior in vitro stimulation of human CD8+ T-cells by whole virus versus split virus influenza vaccinesen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-7868-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titlePLoS onede
jgu.journal.volume9de
jgu.journal.issue7de
jgu.pages.alternativee103392de
jgu.publisher.year2014-
jgu.publisher.namePLoSde
jgu.publisher.placeLawrence, Kan.de
jgu.publisher.urihttp://dx.doi.org/10.1371/journal.pone.0103392de
jgu.publisher.issn1932-6203de
jgu.organisation.placeMainz-
jgu.identifier.pmid25072749
jgu.subject.ddccode610de
opus.date.modified2018-08-08T09:16:11Z
opus.subject.dfgcode00-000
opus.organisation.stringFB 04: Medizin: Institut für Virologiede_DE
opus.organisation.stringFB 04: Medizin: Institut für Immunologiede_DE
opus.organisation.stringFB 04: Medizin: I. Medizinische Klinik und Poliklinikde_DE
opus.organisation.stringFB 04: Medizin: III. Medizinische Klinik und Poliklinikde_DE
opus.identifier.opusid27388
opus.importsourcepubmed
opus.institute.number0409
opus.institute.number0412
opus.institute.number0425
opus.institute.number0427
opus.metadataonlyfalse
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN
opus.affiliatedDistler, Eva
opus.affiliatedWagner, Eva Maria
opus.affiliatedPlachter, Bodo
opus.affiliatedProbst, Hans Christian
opus.affiliatedStrand, Dennis
opus.affiliatedHartwig, Udo
jgu.publisher.doi10.1371/journal.pone.0103392de
jgu.organisation.rorhttps://ror.org/023b0x485-
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