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Authors: Moergel, Maximilian
Kämmerer, Peer
Kasaj, Adrian
Armouti, Evangelia
Alshihri, Abdulmonem
Weyer, Veronika
Al-Nawas, Bilal
Title: Chronic periodontitis and its possible association with oral squamous cell carcinoma : a retrospective case control study
Online publication date: 15-Sep-2022
Year of first publication: 2013
Language: english
Abstract: INTRODUCTION: Different inflammatory processes may trigger the development of malignancies. Therefore, the aim of the present study was to evaluate a potential association between radiological determined chronic periodontitis (CPA) and oral squamous cell carcinoma (OSCC). METHODS: In a retrospective study, OSCC-patients and a control group without malignant tumors were radiographically examined for bone loss. Via telephone survey and questionnaire, general clinical data on the individual oral hygiene and concomitant diseases together with tobacco and alcohol use were assessed and data were compared between the groups. RESULTS: 178 OSCC-patients and 123 controls were included. In univariate analysis, a statistically relevant higher mean bone loss was seen in the OSCC group (4.3 mm (SD: 1.8; 95% confidence interval (CI): 4-4.6) vs. 2.9 mm (SD: 0.7; 95% CI: 2.8-3); p < 0.001)). This was confirmed in a multivariate regression model (OR: 2.4, 95% CI: 1.5-3.8; p < 0.001). A history of periodontal treatment was associated with significantly reduced OSCC risk (p < 0.001; OR: 0.2, CI: 0.1-0.5). CONCLUSIONS: CPA is a common disease and the monitoring as well as the treatment of such a chronic oral inflammation may be beneficial in reducing one potential cause of OSCC. Therefore, further clinical studies on oral neoplasms should consider clinical periodontal parameters as well.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Head & face medicine
Pages or article number: Art. 39
Publisher: BioMed Central
Publisher place: London
Issue date: 2013
ISSN: 1746-160X
Publisher URL:
Publisher DOI: 10.1186/1746-160X-9-39
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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