Authors:	Frühbeis, Carsten Helmig, Susanne Tug, Suzan Simon, Perikles Albers, Eva-Maria
Title:	Physical exercise induces rapid release of small extracellular vesicles into the circulation
Online publication date:	15-Sep-2022
Year of first publication:	2015
Language:	english
Abstract:	Cells secrete extracellular vesicles (EVs) by default and in response to diverse stimuli for the purpose of cell communication and tissue homeostasis. EVs are present in all body fluids including peripheral blood, and their appearance correlates with specific physiological and pathological conditions. Here, we show that physical activity is associated with the release of nano-sized EVs into the circulation. Healthy individuals were subjected to an incremental exercise protocol of cycling or running until exhaustion, and EVs were isolated from blood plasma samples taken before, immediately after and 90 min after exercise. Small EVs with the size of 100-130 nm, that carried proteins characteristic of exosomes, were significantly increased immediately after cycling exercise and declined again within 90 min at rest. In response to treadmill running, elevation of small EVs was moderate but appeared more sustained. To delineate EV release kinetics, plasma samples were additionally taken at the end of each increment of the cycling exercise protocol. Release of small EVs into the circulation was initiated in an early phase of exercise, before the individual anaerobic threshold, which is marked by the rise of lactate. Taken together, our study revealed that exercise triggers a rapid release of EVs with the characteristic size of exosomes into the circulation, initiated in the aerobic phase of exercise. We hypothesize that EVs released during physical activity may participate in cell communication during exercise-mediated adaptation processes that involve signalling across tissues and organs.
DDC:	570 Biowissenschaften 570 Life sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 02 Sozialwiss., Medien u. Sport FB 10 Biologie
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7770
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	Journal of extracellular vesicles 4
Pages or article number:	Art. 28239
Publisher:	Co-Action Publ.
Issue date:	2015
ISSN:	2001-3078
Publisher URL:	http://dx.doi.org/10.3402/jev.v4.28239
Publisher DOI:	10.3402/jev.v4.28239
Annotation:	Albers, Eva-Maria veröffentlicht auch unter Krämer-Albers, Eva-Maria
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)