Gutenberg Open Science: The effect of polyphenols on protein degradation pathways : implications for neuroprotection

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7759

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DC Field	Value	Language
dc.contributor.author	Hajieva, Parvana	-
dc.date.accessioned	2022-09-14T08:27:14Z	-
dc.date.available	2022-09-14T08:27:14Z	-
dc.date.issued	2017
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7774	-
dc.description.abstract	Human neurodegenerative diseases are accompanied by accumulation of heavily oxidized and aggregated proteins. however, the exact molecular reason is not fully elucidated yet. insufficient cellular protein quality control is thought to play an important role in accumulating covalently oxidized misfolded proteins. pharmacologically active polyphenols and their derivatives exhibit potential for preventive and therapeutic purposes against protein aggregation during neurodegeneration. although these compounds act on various biochemical pathways, their role in stabilizing the protein degradation machinery at different stages may be an attractive therapeutical strategy to halt the accumulation of misfolded proteins. this review evaluates and discusses the existing scientific literature on the effect of polyphenols on three major protein degradation pathways: chaperone-mediated autophagy, the proteasome and macroautophagy. the results of these studies demonstrate that phenolic compounds are able to influence the major protein degradation pathways at different levels.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	The effect of polyphenols on protein degradation pathways : implications for neuroprotection	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7759	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Molecules	de
jgu.journal.volume	22	de
jgu.journal.issue	1	de
jgu.pages.alternative	Art. 159	de
jgu.publisher.year	2017	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	http://dx.doi.org/10.3390/molecules22010159	de
jgu.publisher.issn	1420-3049	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-03-13T08:33:51Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Institut für Physiologische Chemie und Pathobiochemie	de_DE
opus.identifier.opusid	57970
opus.institute.number	0404
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Hajieva, Parvana
jgu.publisher.doi	10.3390/molecules22010159	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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