Authors:	Hajieva, Parvana
Title:	The effect of polyphenols on protein degradation pathways : implications for neuroprotection
Online publication date:	14-Sep-2022
Year of first publication:	2017
Language:	english
Abstract:	Human neurodegenerative diseases are accompanied by accumulation of heavily oxidized and aggregated proteins. however, the exact molecular reason is not fully elucidated yet. insufficient cellular protein quality control is thought to play an important role in accumulating covalently oxidized misfolded proteins. pharmacologically active polyphenols and their derivatives exhibit potential for preventive and therapeutic purposes against protein aggregation during neurodegeneration. although these compounds act on various biochemical pathways, their role in stabilizing the protein degradation machinery at different stages may be an attractive therapeutical strategy to halt the accumulation of misfolded proteins. this review evaluates and discusses the existing scientific literature on the effect of polyphenols on three major protein degradation pathways: chaperone-mediated autophagy, the proteasome and macroautophagy. the results of these studies demonstrate that phenolic compounds are able to influence the major protein degradation pathways at different levels.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7759
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Molecules 22 1
Pages or article number:	Art. 159
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2017
ISSN:	1420-3049
Publisher URL:	http://dx.doi.org/10.3390/molecules22010159
Publisher DOI:	10.3390/molecules22010159
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)