Autoren:	Hajieva, Parvana
Titel:	The effect of polyphenols on protein degradation pathways : implications for neuroprotection
Online-Publikationsdatum:	14-Sep-2022
Erscheinungsdatum:	2017
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Human neurodegenerative diseases are accompanied by accumulation of heavily oxidized and aggregated proteins. however, the exact molecular reason is not fully elucidated yet. insufficient cellular protein quality control is thought to play an important role in accumulating covalently oxidized misfolded proteins. pharmacologically active polyphenols and their derivatives exhibit potential for preventive and therapeutic purposes against protein aggregation during neurodegeneration. although these compounds act on various biochemical pathways, their role in stabilizing the protein degradation machinery at different stages may be an attractive therapeutical strategy to halt the accumulation of misfolded proteins. this review evaluates and discusses the existing scientific literature on the effect of polyphenols on three major protein degradation pathways: chaperone-mediated autophagy, the proteasome and macroautophagy. the results of these studies demonstrate that phenolic compounds are able to influence the major protein degradation pathways at different levels.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7759
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Molecules 22 1
Seitenzahl oder Artikelnummer:	Art. 159
Verlag:	MDPI
Verlagsort:	Basel
Erscheinungsdatum:	2017
ISSN:	1420-3049
URL der Originalveröffentlichung:	http://dx.doi.org/10.3390/molecules22010159
DOI der Originalveröffentlichung:	10.3390/molecules22010159
Enthalten in den Sammlungen:	DFG-OA-Publizieren (2012 - 2017)