Authors:	Imbrosci, Barbara Neitz, Angela Mittmann, Thomas
Title:	Physiological properties of supragranular cortical inhibitory interneurons expressing retrograde persistent firing
Online publication date:	14-Sep-2022
Year of first publication:	2015
Language:	english
Abstract:	Neurons are polarized functional units. The somatodendritic compartment receives and integrates synaptic inputs while the axon relays relevant synaptic information in form of action potentials (APs) across long distance. Despite this well accepted notion, recent research has shown that, under certain circumstances, the axon can also generate APs independent of synaptic inputs at axonal sites distal from the soma. These ectopic APs travel both toward synaptic terminals and antidromically toward the soma. This unusual form of neuronal communication seems to preferentially occur in cortical inhibitory interneurons following a period of intense neuronal activity and might have profound implications for neuronal information processing. Here we show that trains of ectopically generated APs can be induced in a large portion of neocortical layer 2/3 GABAergic interneurons following a somatic depolarization inducing hundreds of APs. Sparsely occurring ectopic spikes were also observed in a large portion of layer 1 interneurons even in absence of prior somatic depolarization. Remarkably, we found that interneurons which produce ectopic APs display specific membrane and morphological properties significantly different from the remaining GABAergic cells and may therefore represent a functionally unique interneuronal subpopulation.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7751
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/3.0/
Journal:	Neural plasticity 2015
Pages or article number:	Art. 608141
Publisher:	Hindawi
Publisher place:	New York, NY
Issue date:	2015
ISSN:	1687-5443 2090-5904
Publisher URL:	http://dx.doi.org/10.1155/2015/608141
Publisher DOI:	10.1155/2015/608141
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)