Gutenberg Open Science: Mental health and health-related quality of life in preschool-aged childhood cancer survivors : results of the prospective cohort study ikidS-OEVA

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7719

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DC Field	Value	Language
dc.contributor.author	Neu, Marie A.	-
dc.contributor.author	Schlecht, Jennifer	-
dc.contributor.author	Schmidt, Martina F.	-
dc.contributor.author	Robinson, Abigale L.	-
dc.contributor.author	Spix, Claudia	-
dc.contributor.author	Grabow, Desiree	-
dc.contributor.author	Kaatsch, Peter	-
dc.contributor.author	Erdmann, Friederike	-
dc.contributor.author	Faber, Jörg	-
dc.contributor.author	Urschitz, Michael S.	-
dc.contributor.other	The IkidS Study Group	-
dc.date.accessioned	2022-09-12T09:41:24Z	-
dc.date.available	2022-09-12T09:41:24Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7734	-
dc.description.abstract	Objectives Long-term survivors of childhood cancer are at increased risk for sequelae such as poor mental health (MH) or impaired health-related quality of life (HrQoL). We aimed to evaluate early adverse effects on MH and HrQoL in young childhood cancer survivors (YCCS) before school entry. Methods In a nationwide prospective cohort study, children with cancer other than brain tumors diagnosed at preschool age and completed cancer treatments were identified from the German Childhood Cancer Registry. The comparison group was children of the same age without a cancer diagnosis who participated in the prospective population-based health survey ikidS. MH problems and HrQoL were assessed by parental versions of the Strengths and Difficulties Questionnaire (SDQ) and the questionnaire for health-related quality of life in children (KINDL), respectively. Associations between cancer and MH as well as HrQoL were analyzed by multivariable linear regression. Results Of 382 YCCS contacted, 145 were enrolled (mean age 6.6 years) and 124 analyzed. Compared to children without a cancer diagnosis (3683 contacted, 2003 enrolled, 1422 analyzed), YCCS had more MH problems (13% vs. 3%) and slightly worse HrQoL (median 78.7 vs. 80.2 points). In the adjusted analysis, YCCS had higher SDQ scores (2.2 points, 95% confidence interval [CI] 1.3, 3.0) and lower KINDL scores (−2.4 points, 95% CI −3.7, −1.1) compared to children without cancer diagnosis. Conclusion Already at preschool age, YCCS may be at increased risk of MH problems and impaired HrQoL. This could have impacts on subsequent school performance and educational attainment. Follow-up health care for YCCS may include early screening for MH problems and reasons for HrQoL deficits.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC-ND	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Mental health and health-related quality of life in preschool-aged childhood cancer survivors : results of the prospective cohort study ikidS-OEVA	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7719	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Pediatric blood & cancer	de
jgu.journal.volume	68	de
jgu.journal.issue	8	de
jgu.pages.alternative	e29039	de
jgu.publisher.year	2021	-
jgu.publisher.name	Wiley	de
jgu.publisher.place	New York, NY	de
jgu.publisher.issn	1545-5017	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1002/pbc.29039	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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