Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7687
Authors: | Wagner, Felix M. Schuster, Alexander K. Munder, Annika Muehl, Marius Chronopoulos, Panagiotis Pfeiffer, Norbert Hoffmann, Esther M. |
Title: | Comparison of subconjunctival microinvasive glaucoma surgery and trabeculectomy |
Online publication date: | 6-Sep-2022 |
Year of first publication: | 2022 |
Language: | english |
Abstract: | Purpose To assess surgical success and the post-operative development of intraocular pressure between XEN45® gelstent, Preserflo® MicroShunt and trabeculectomy with mitomycin C. Methods Data from 105 eyes from 105 patients of matched cases with refractory open-angle glaucoma, who underwent surgery between January 2019, and August 2020, were evaluated. Patients underwent either stand-alone XEN gelstent insertion with Mitomycin C, stand-alone Preserflo with Mitomycin C or trabeculectomy with Mitomycin C. The primary outcome was the proportion of complete surgical success at 6 months post-operatively (i.e. intraocular pressure between 5mmHg and 18mmHg, no revision surgery, no loss of light perception and no post-operative pharmaceutical antiglaucomatous treatment). The reduction of intraocular pressure after 6 months, the classes of antiglaucomatous medication used post-operatively, best-corrected visual acuity, spherical refractive errors and astigmatism were assessed as secondary outcomes. Results We included 35 eyes in each group. After 6-month follow-up, complete success was 73.5% [95%-CI: 57.9%–89.2%] in the trabeculectomy group, 51.4% [95%-CI: 34.0%–68.8%] in the XEN group and 74.2% [95%-CI: 57.9%–90.5%] in the Preserflo group (p = 0.08). Regarding secondary outcomes, the reduction of intraocular pressure was 12.1 ± 7.9 mmHg in the trabeculectomy group and was thereby 5.8 [95%-CI: 2.2–9.6] mmHg greater compared with the XEN group (p < 0.001) and 4.8 [95%-CI: 0.9–8.7] mmHg higher than the Preserflo group (p = 0.01). Conclusions No statistically significant differences were found between trabeculectomy, XEN45® gelstent implantation and Preserflo® MicroShunt implantation regarding surgical success after 6 months. Yet reduction in intraocular pressure was significantly higher in the trabeculectomy group. However, all three interventions resulted in sufficiently low post-operative intraocular pressure and may therefore be considered individually for glaucoma treatment. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7687 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY-NC |
Information on rights of use: | https://creativecommons.org/licenses/by-nc/4.0/ |
Journal: | Acta ophthalmologica 100 5 |
Pages or article number: | e1120 e1126 |
Publisher: | Wiley-Blackwell |
Publisher place: | Oxford |
Issue date: | 2022 |
ISSN: | 1755-3768 |
Publisher DOI: | 10.1111/aos.15042 |
Appears in collections: | JGU-Publikationen |
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File | Description | Size | Format | ||
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comparison_of_subconjunctival-20220902160957549.pdf | 367.51 kB | Adobe PDF | View/Open |