Gutenberg Open Science: Comparison of subconjunctival microinvasive glaucoma surgery and trabeculectomy

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7687

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DC Field	Value	Language
dc.contributor.author	Wagner, Felix M.	-
dc.contributor.author	Schuster, Alexander K.	-
dc.contributor.author	Munder, Annika	-
dc.contributor.author	Muehl, Marius	-
dc.contributor.author	Chronopoulos, Panagiotis	-
dc.contributor.author	Pfeiffer, Norbert	-
dc.contributor.author	Hoffmann, Esther M.	-
dc.date.accessioned	2022-09-06T10:12:46Z	-
dc.date.available	2022-09-06T10:12:46Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7702	-
dc.description.abstract	Purpose To assess surgical success and the post-operative development of intraocular pressure between XEN45® gelstent, Preserflo® MicroShunt and trabeculectomy with mitomycin C. Methods Data from 105 eyes from 105 patients of matched cases with refractory open-angle glaucoma, who underwent surgery between January 2019, and August 2020, were evaluated. Patients underwent either stand-alone XEN gelstent insertion with Mitomycin C, stand-alone Preserflo with Mitomycin C or trabeculectomy with Mitomycin C. The primary outcome was the proportion of complete surgical success at 6 months post-operatively (i.e. intraocular pressure between 5mmHg and 18mmHg, no revision surgery, no loss of light perception and no post-operative pharmaceutical antiglaucomatous treatment). The reduction of intraocular pressure after 6 months, the classes of antiglaucomatous medication used post-operatively, best-corrected visual acuity, spherical refractive errors and astigmatism were assessed as secondary outcomes. Results We included 35 eyes in each group. After 6-month follow-up, complete success was 73.5% [95%-CI: 57.9%–89.2%] in the trabeculectomy group, 51.4% [95%-CI: 34.0%–68.8%] in the XEN group and 74.2% [95%-CI: 57.9%–90.5%] in the Preserflo group (p = 0.08). Regarding secondary outcomes, the reduction of intraocular pressure was 12.1 ± 7.9 mmHg in the trabeculectomy group and was thereby 5.8 [95%-CI: 2.2–9.6] mmHg greater compared with the XEN group (p < 0.001) and 4.8 [95%-CI: 0.9–8.7] mmHg higher than the Preserflo group (p = 0.01). Conclusions No statistically significant differences were found between trabeculectomy, XEN45® gelstent implantation and Preserflo® MicroShunt implantation regarding surgical success after 6 months. Yet reduction in intraocular pressure was significantly higher in the trabeculectomy group. However, all three interventions resulted in sufficiently low post-operative intraocular pressure and may therefore be considered individually for glaucoma treatment.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Comparison of subconjunctival microinvasive glaucoma surgery and trabeculectomy	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7687	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Acta ophthalmologica	de
jgu.journal.volume	100	de
jgu.journal.issue	5	de
jgu.pages.start	e1120	de
jgu.pages.end	e1126	de
jgu.publisher.year	2022	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Oxford	de
jgu.publisher.issn	1755-3768	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/aos.15042	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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