Gutenberg Open Science: Cardiac late effects after modern 3D-conformal radiotherapy in breast cancer patients : a retrospective cohort study in Germany (ESCaRa)

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7647

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DC Field	Value	Language
dc.contributor.author	Merzenich, Hiltrud	-
dc.contributor.author	Baaken, Dan	-
dc.contributor.author	Schmidt, Marcus	-
dc.contributor.author	Bekes, Inga	-
dc.contributor.author	Schwentner, Lukas	-
dc.contributor.author	Janni, Wolfgang	-
dc.contributor.author	Woeckel, Achim	-
dc.contributor.author	Bartkowiak, Detlef	-
dc.contributor.author	Wiegel, Thomas	-
dc.contributor.author	Blettner, Maria	-
dc.contributor.author	Wollschläger, Daniel	-
dc.contributor.author	Schmidberger, Heinz	-
dc.date.accessioned	2022-08-30T10:26:15Z	-
dc.date.available	2022-08-30T10:26:15Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7661	-
dc.description.abstract	Purpose Radiotherapy (RT) was identified as a risk factor for long-term cardiac effects in breast cancer patients treated until the 1990s. However, modern techniques reduce radiation exposure of the heart, but some exposure remains unavoidable. In a retrospective cohort study, we investigated cardiac mortality and morbidity of breast cancer survivors treated with recent RT in Germany. Methods A total of 11,982 breast cancer patients treated between 1998 and 2008 were included. A mortality follow-up was conducted until 06/2018. In order to assess cardiac morbidity occurring after breast cancer treatment, a questionnaire was sent out in 2014 and 2019. The effect of breast cancer laterality on cardiac mortality and morbidity was investigated as a proxy for radiation exposure. We used Cox Proportional Hazards regression analysis, taking potential confounders into account. Results After a median follow-up time of 11.1 years, there was no significant association of tumor laterality with cardiac mortality in irradiated patients (hazard ratio (HR) for left-sided versus right-sided tumor 1.09; 95% confidence interval (CI) 0.85–1.41). Furthermore, tumor laterality was not identified as a significant risk factor for cardiac morbidity (HR = 1.05; 95%CI 0.88–1.25). Conclusions Even though RT for left-sided breast cancer on average incurs higher radiation dose to the heart than RT for right-sided tumors, we found no evidence that laterality is a strong risk factor for cardiac disease after contemporary RT. However, larger sample sizes, longer follow-up, detailed information on individual risk factors and heart dose are needed to assess clinically manifest late effects of current cancer therapy.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Cardiac late effects after modern 3D-conformal radiotherapy in breast cancer patients : a retrospective cohort study in Germany (ESCaRa)	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7647	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Breast cancer research and treatment	de
jgu.journal.volume	191	de
jgu.pages.start	147	de
jgu.pages.end	157	de
jgu.publisher.year	2022	-
jgu.publisher.name	Springer Science + Business Media B.V.	de
jgu.publisher.place	Dordrecht u.a.	de
jgu.publisher.issn	1573-7217	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1007/s10549-021-06412-3	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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