1. Startpage
  2. Johannes Gutenberg-Universität Mainz
  3. JGU-Publikationen
Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7628
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBrandt, Maximilian Peter-
dc.contributor.authorRuf, Christian-
dc.contributor.authorDieckmann, Klaus Peter-
dc.contributor.authorSyring, Isabella-
dc.contributor.authorRuckes, Christian-
dc.contributor.authorNestler, Tim-
dc.contributor.authorSchmelz, H. U.-
dc.contributor.authorDotzauer, Robert-
dc.contributor.authorHiester, Andreas-
dc.contributor.authorAlbers, Pete-
dc.contributor.authorNettersheim, Daniel-
dc.contributor.authorBolenz, Christian-
dc.contributor.authorLoosen, Sven H.-
dc.contributor.authorHeidenreich, Axel-
dc.contributor.authorPfister, Darren-
dc.contributor.authorHaferkamp, Axel-
dc.contributor.authorZengerling, Friedemann-
dc.contributor.authorPaffenholz, Pia-
dc.date.accessioned2022-08-29T10:14:47Z-
dc.date.available2022-08-29T10:14:47Z-
dc.date.issued2022-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7642-
dc.description.abstractPurpose Clinical stage I (CSI) testicular germ cell tumors (TGCT) represents disease confined to the testis without metastasis and CSIS is defined as persistently elevated tumor markers (TM) after orchiectomy, indicating subclinical metastatic disease. This study aims at assessing clinical characteristics and oncological outcome in CSIS. Methods Data from five tertiary referring centers in Germany were screened. We defined correct classification of CSIS according to EAU guidelines. TM levels, treatment and relapse-free survival were assessed and differences between predefined groups (chemotherapy, correct/incorrect CSIS) were analyzed with Fisher’s exact and Chi-square test. Results Out of 2616 TGCT patients, 43 (1.6%) were CSIS. Thereof, 27 were correctly classified (cCSIS, 1.03%) and 16 incorrectly classified (iCSIS). TMs that defined cCSIS were in 12 (44.4%), 10 (37%), 3 (11.1%) and 2 (7.4%) patients AFP, ß-HCG, AFP plus ß-HCG and LDH, respectively. In the cCSIS group, six patients were seminoma and 21 non-seminoma. Treatment consisted of active surveillance, carboplatin-mono AUC7 and BEP (bleomycin, etoposide and cisplatin). No difference between cCSIS and iCSIS with respect to applied chemotherapy was found (p = 0.830). 5-year relapse-free survival was 88.9% and three patients (11%) in the cCSIS group relapsed. All underwent salvage treatment (3xBEP) with no documented death. Conclusion Around 1% of all TGCT were classified as cCSIS patients. Identification of cCSIS is of critical importance to avoid disease progression and relapses by adequate treatment. We report a high heterogeneity of treatment patterns, associated with excellent long-term survival irrespective of the initial treatment approach.en_GB
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleClinical characteristics, treatment patterns and relapse in patients with clinical stage IS testicular canceren_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-7628-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleWorld journal of urologyde
jgu.journal.volume40de
jgu.pages.start327de
jgu.pages.end334de
jgu.publisher.year2022-
jgu.publisher.nameSpringerde
jgu.publisher.placeBerlin u.a.de
jgu.publisher.issn1433-8726de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
jgu.publisher.doi10.1007/s00345-021-03889-xde
jgu.organisation.rorhttps://ror.org/023b0x485-
Appears in collections:JGU-Publikationen

Files in This Item:
  File Description SizeFormat
Thumbnail
clinical_characteristics_trea-20220826151952870.pdf812.65 kBAdobe PDFView/Open
Show simple item record