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Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-757
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dc.contributor.authorShen, Limei-
dc.contributor.authorTenzer, Stefan-
dc.contributor.authorHess, Moritz-
dc.contributor.authorDistler, Ute-
dc.contributor.authorTubbe, Ingrid-
dc.contributor.authorMontermann, Evelyn-
dc.contributor.authorSchimmer, Simone-
dc.contributor.authorDittmer, Ulf-
dc.contributor.authorGrabbe, Stephan-
dc.contributor.authorBros, Matthias-
dc.date.accessioned2018-11-26T14:41:37Z-
dc.date.available2018-11-26T15:41:37Z-
dc.date.issued2018-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/759-
dc.description.abstractThe murine Friend virus (FV) retrovirus model has been widely used to study anti-viral immune responses, and virus-induced cancer. Here we analyzed FV immune evasion mechanisms on the level of dendritic cells (DC) essential for the induction of primary adaptive immune responses. Comparative quantitative proteome analysis of FV-infected DC (FV-DC) of different genotypes (BALB/c, C57BL/6) and non-infected DC revealed numerous genotype-independently regulated proteins rergulating metabolic activity, cytoskeletal rearrangements, and antigen processing/presentation. These alterations may promote virion production in FV-DC. Stimulation of FV-DC with LPS resulted in strongly enhanced IL-10 production which was partially responsible for their attenuated T cell (CD4 , CD8 ) stimulatory capacity. Stimulated FV-DC induced less IFN-γ production in T cells required for cellular anti-viral responses, but more T helper cell type 2 (Th2)-associated cytokines (IL-4, IL-5, IL-13). We conclude that FV reprograms DC to promote viral spreading and immune deviation by imprinting a largely maturation-resistant, Th2-biased immunophenotype.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin-
dc.language.isoeng-
dc.rightsCC BYde_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleFriend virus limits adaptive cellular immune responses by imprinting a maturation-resistant and T helper type 2-biased immunophenotype in dendritic cellsen_GB
dc.typeZeitschriftenaufsatzde_DE
dc.identifier.urnurn:nbn:de:hebis:77-publ-586564-
dc.identifier.doihttp://doi.org/10.25358/openscience-757-
jgu.type.dinitypearticle-
jgu.type.versionPublished versionen_GB
jgu.type.resourceText-
jgu.organisation.departmentFB 04 Medizin-
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titlePLOS ONE-
jgu.journal.volume13-
jgu.journal.issue2-
jgu.pages.alternativee0192541-
jgu.publisher.year2018-
jgu.publisher.namePLOS-
jgu.publisher.placeSan Francisco, California, US-
jgu.publisher.urihttp://dx.doi.org/10.1371/journal.pone.0192541-
jgu.publisher.issn1932-6203-
jgu.organisation.placeMainz-
jgu.subject.ddccode610-
opus.date.accessioned2018-11-26T14:41:37Z-
opus.date.modified2018-11-28T08:54:54Z-
opus.date.available2018-11-26T15:41:37-
opus.subject.dfgcode00-000-
opus.organisation.stringFB 04: Medizin: Hautklinikde_DE
opus.organisation.stringFB 04: Medizin: Institut für Klinische Chemie und Laboratoriumsmedizinde_DE
opus.organisation.stringFB 04: Medizin: Institut für Immunologiede_DE
opus.identifier.opusid58656-
opus.institute.number0431-
opus.institute.number0428-
opus.institute.number0412-
opus.metadataonlyfalse-
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_GB
opus.affiliatedTenzer, Stefan-
opus.affiliatedGrabbe, Stephan-
opus.affiliatedBros, Matthias-
jgu.publisher.doi10.1371/journal.pone.0192541
jgu.organisation.rorhttps://ror.org/023b0x485
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