Authors:	Yang, Jenq-Wei Reyes-Puerta, Vicente Kilb, Werner Luhmann, Heiko
Title:	Spindle bursts in neonatal rat cerebral cortex
Online publication date:	18-Aug-2022
Year of first publication:	2016
Language:	english
Abstract:	Spontaneous and sensory evoked spindle bursts represent a functional hallmark of the developing cerebral cortex in vitro and in vivo. They have been observed in various neocortical areas of numerous species, including newborn rodents and preterm human infants. Spindle bursts are generated in complex neocortical-subcortical circuits involving in many cases the participation of motor brain regions. Together with early gamma oscillations, spindle bursts synchronize the activity of a local neuronal network organized in a cortical column. Disturbances in spindle burst activity during corticogenesis may contribute to disorders in cortical architecture and in the activity-dependent control of programmed cell death. In this review we discuss (i) the functional properties of spindle bursts, (ii) the mechanisms underlying their generation, (iii) the synchronous patterns and cortical networks associated with spindle bursts, and (iv) the physiological and pathophysiological role of spindle bursts during early cortical development.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7570
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Neural plasticity 2016
Pages or article number:	Art. 3467832
Publisher:	Hindawi
Publisher place:	New York, NY
Issue date:	2016
ISSN:	1687-5443 2090-5904 0792-8483
Publisher URL:	http://dx.doi.org/10.1155/2016/3467832
Publisher DOI:	10.1155/2016/3467832
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)