Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7350
Authors: Schmidt, Hanno
Malik, Assaf
Bicker, Anne
Poetzsch, Gesa
Avivi, Aaron
Shams, Imad
Hankeln, Thomas
Title: Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax : a liver transcriptomics approach
Online publication date: 11-Jul-2022
Language: english
Abstract: The blind subterranean mole rat Spalax shows a remarkable tolerance to hypoxia, cancer-resistance and longevity. Unravelling the genomic basis of these adaptations will be important for biomedical applications. RNA-Seq gene expression data were obtained from normoxic and hypoxic Spalax and rat liver tissue. Hypoxic Spalax broadly downregulates genes from major liver function pathways. This energy-saving response is likely a crucial adaptation to low oxygen levels. In contrast, the hypoxia-sensitive rat shows massive upregulation of energy metabolism genes. Candidate genes with plausible connections to the mole rat’s phenotype, such as important key genes related to hypoxia-tolerance, DNA damage repair, tumourigenesis and ageing, are substantially higher expressed in Spalax than in rat. Comparative liver transcriptomics highlights the importance of molecular adaptations at the gene regulatory level in Spalax and pinpoints a variety of starting points for subsequent functional studies.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 10 Biologie
Place: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-7350
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
Information on rights of use: https://creativecommons.org/licenses/by/4.0/
Journal: Scientific reports
7
Pages or article number: Art. 14348
Publisher: Nature Publ. Group
Publisher place: London
Issue date: 2017
ISSN: 2045-2322
Publisher URL: http://dx.doi.org/10.1038/s41598-017-13905-z
Publisher DOI: 10.1038/s41598-017-13905-z
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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