Authors:	Ruemmler, Robert Ziebart, Alexander Britten, Elisabeth Gosling, Moritz Rissel, Rene Hartmann, Erik K.
Title:	Intrabronchial application of extracellular histones shows no proinflammatory effects in swine in a translational pilot study
Online publication date:	5-Jul-2022
Year of first publication:	2021
Language:	english
Abstract:	Objective Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted to validate the proinflammatory in vivo effects of local histone application in a prospective translational porcine model. This was combined with the evaluation of an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has been published previously. Results The targeted application of histones was successful in all animals. Animals showed decreased oxygenation after instillation, but no differences could be detected between the sham and histone treatments. The histologic analyses and inflammatory responses indicated that there were no differences in tissue damage between the groups.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7311
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	BMC Research Notes 14
Pages or article number:	285
Publisher:	BioMed Central
Publisher place:	London
Issue date:	2021
ISSN:	1756-0500
Publisher DOI:	10.1186/s13104-021-05704-7
Appears in collections:	JGU-Publikationen