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Authors: Hammerschmidt, Stefan Josef
Müller, Patrick
Schirmeister, Tanja
Title: SARS-CoV-PLpro-Inhibitoren als mögliche Breitspektrum-Virostatika
Online publication date: 4-Jul-2022
Year of first publication: 2021
Language: german
Abstract: The SARS-CoV-encoded papain-like cysteine protease (PLpro) plays crucial roles in viral replication and maturation processes. It is required to cleave the precursor polyproteins into functional proteins. Thus, it is considered to be a promising target for developing specific drugs. For rational optimization of hit compounds, information about the structure-activity relationship (SAR) is fundamental. Herein, we characterize isoindolines as a new class of PLpro inhibitors.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 09 Chemie, Pharmazie u. Geowissensch.
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Biospektrum
Pages or article number: 254
Publisher: Spektrum
Publisher place: Heidelberg
Issue date: 2021
ISSN: 1868-6249
Publisher DOI: 10.1007/s12268-021-1576-6
Appears in collections:JGU-Publikationen

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