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http://doi.org/10.25358/openscience-7288| Authors: | Hammerschmidt, Stefan Josef Müller, Patrick Schirmeister, Tanja |
| Title: | SARS-CoV-PLpro-Inhibitoren als mögliche Breitspektrum-Virostatika |
| Online publication date: | 4-Jul-2022 |
| Year of first publication: | 2021 |
| Language: | german |
| Abstract: | The SARS-CoV-encoded papain-like cysteine protease (PLpro) plays crucial roles in viral replication and maturation processes. It is required to cleave the precursor polyproteins into functional proteins. Thus, it is considered to be a promising target for developing specific drugs. For rational optimization of hit compounds, information about the structure-activity relationship (SAR) is fundamental. Herein, we characterize isoindolines as a new class of PLpro inhibitors. |
| DDC: | 610 Medizin 610 Medical sciences |
| Institution: | Johannes Gutenberg-Universität Mainz |
| Department: | FB 09 Chemie, Pharmazie u. Geowissensch. |
| Place: | Mainz |
| ROR: | https://ror.org/023b0x485 |
| DOI: | http://doi.org/10.25358/openscience-7288 |
| Version: | Published version |
| Publication type: | Zeitschriftenaufsatz |
| License: | CC BY |
| Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
| Journal: | Biospektrum 27 |
| Pages or article number: | 254 256 |
| Publisher: | Spektrum |
| Publisher place: | Heidelberg |
| Issue date: | 2021 |
| ISSN: | 1868-6249 |
| Publisher DOI: | 10.1007/s12268-021-1576-6 |
| Appears in collections: | JGU-Publikationen |
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| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | sarscovplproinhibitoren_als_m-20220701134011960.pdf | 437.29 kB | Adobe PDF | View/Open |