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http://doi.org/10.25358/openscience-7237Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Geyer, Martin | - |
| dc.contributor.author | Keller, Karsten | - |
| dc.contributor.author | Bachmann, Kevin | - |
| dc.contributor.author | Born, Sonja | - |
| dc.contributor.author | Tamm, Alexander R. | - |
| dc.contributor.author | Ruf, Tobias Friedrich | - |
| dc.contributor.author | Kreidel, Felix | - |
| dc.contributor.author | Hahad, Omar | - |
| dc.contributor.author | Petrescu, Aniela | - |
| dc.contributor.author | Hell, Michaela | - |
| dc.contributor.author | Beiras-Fernandez, Andres | - |
| dc.contributor.author | Kornberger, Angela | - |
| dc.contributor.author | Schulz, Eberhard | - |
| dc.contributor.author | Münzel, Thomas | - |
| dc.contributor.author | Bardeleben, Ralph Stephan von | - |
| dc.date.accessioned | 2022-06-28T08:20:59Z | - |
| dc.date.available | 2022-06-28T08:20:59Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/7251 | - |
| dc.description.abstract | BACKGROUND Concomitant tricuspid regurgitation (TR) is a common finding in mitral regurgitation (MR). Transcatheter repair (TMVR) is a favorable treatment option in patients at elevated surgical risk. To date, evidence on long-term prognosis and the prognostic impact of TR after TMVR is limited. METHODS Long-term survival data of patients undergoing isolated edge-to-edge repair from June 2010 to March 2018 (combinations with other forms of TMVR or tricuspid valve therapy excluded) were analyzed in a retrospective monocentric study. TR severity was categorized and the impact of TR on survival was analysed. RESULTS Overall, 606 patients [46.5% female, 56.4% functional MR (FMR)] were enrolled in this study. TR at baseline was categorized severe/medium/mild/no or trace in 23.2/34.3/36.3/6.3% of the cases. At 30-day follow-up, improvement of at least one TR-grade was documented in 34.9%. Severe TR at baseline was identified as predictor of 1-year survival [65.2% vs. 77.0%, p = 0.030; HR for death 1.68 (95% CI 1.12–2.54), p = 0.013] and in FMR-patients also regarding long-term prognosis [adjusted HR for long-term mortality 1.57 (95% CI 1.00–2.45), p = 0.049]. Missing post-interventional reduction of TR severity was predictive for poor prognosis, especially in the FMR-subgroup [1-year survival: 92.9% vs. 78.3%, p = 0.025; HR for death at 1-year follow-up 3.31 (95% CI 1.15–9.58), p = 0.027]. While BNP levels decreased in both subgroups, TR reduction was associated with improved symptomatic benefit (NYHA-class-reduction 78.6 vs. 65.9%, p = 0.021). CONCLUSION In this large study, both, severe TR at baseline as well as missing secondary reduction were predictive for impaired long-term prognosis, especially in patients with FMR etiology. TR reduction was associated with increased symptomatic benefit. | en_GB |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Concomitant tricuspid regurgitation severity and its secondary reduction determine long-term prognosis after transcatheter mitral valve edge-to-edge repair | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-7237 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Clinical research in cardiology | de |
| jgu.journal.volume | 110 | de |
| jgu.pages.start | 676 | de |
| jgu.pages.end | 688 | de |
| jgu.publisher.year | 2021 | - |
| jgu.publisher.name | Springer | de |
| jgu.publisher.place | Berlin | de |
| jgu.publisher.issn | 1861-0692 | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| jgu.publisher.doi | 10.1007/s00392-020-01798-4 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | JGU-Publikationen | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | concomitant_tricuspid_regurgi-20220627114547951.pdf | 1.04 MB | Adobe PDF | View/Open |