Autoren:	Man, Andy W. C. Xia, Ning Daiber, Andreas Li, Huige
Titel:	The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols
Online-Publikationsdatum:	20-Jun-2022
Erscheinungsdatum:	2020
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Polyphenols are secondary metabolites of plants that have been widely studied for their health benefits as antioxidants. In the last decade, several clinical trials and epidemiological studies have shown that long-term consumption of polyphenol-rich diet protects against chronic diseases such as cancers and cardiovascular diseases. Current cardiovascular studies have also suggested an important role of gut microbiota and circadian rhythm in the pathogenesis metabolic and cardiovascular diseases. It is known that polyphenols can modulate the composition of core gut microbiota and interact with circadian clocks. In this article, we summarize recent findings, review the molecular mechanisms and the potential of polyphenols as dietary supplements for regulating gut microbiota and circadian rhythms, and discuss future research directions.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7179
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY-NC
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by-nc/4.0/
Zeitschrift:	British journal of pharmacology 177 6
Seitenzahl oder Artikelnummer:	1278 1293
Verlag:	Wiley
Verlagsort:	Malden, MA
Erscheinungsdatum:	2020
ISSN:	1476-5381
DOI der Originalveröffentlichung:	10.1111/bph.14850
Enthalten in den Sammlungen:	JGU-Publikationen