Gutenberg Open Science: Spreading depression and focal venous cerebral ischemia enhance cortical neurogenesis

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7132

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DC Field	Value	Language
dc.contributor.author	Tamaki, Ryo	-
dc.contributor.author	Orie, Samuel Ige	-
dc.contributor.author	Alessandri, Beat	-
dc.contributor.author	Kempski, Oliver	-
dc.contributor.author	Heimann, Axel	-
dc.date.accessioned	2022-06-13T10:23:56Z	-
dc.date.available	2022-06-13T10:23:56Z	-
dc.date.issued	2017	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7146	-
dc.description.abstract	Endogenous neurogenesis can arise from a variety of physiological stimuli including exercise, learning, or “enriched environment” as well as pathological conditions such as ischemia, epilepsy or cortical spreading depression. Whether all these conditions use a common trigger to set off endogenous neurogenesis is yet unclear. We hypothesized that cortical spreading depression (CSD) induces neurogenesis in the cerebral cortex and dentate gyrus after cerebral venous ischemia. Forty-two Wistar rats alternatively underwent sham operation (Sham), induction of ten CSDs or venous ischemia provoked via occlusion of two adjacent superficial cortical vein followed by ten induced CSDs (CSD + 2-VO). As an additional control, 15 naïve rats received no intervention except 5-bromo-2′-deoxyuridine (BrdU) treatment for 7 days. Sagittal brain slices (40 μm thick) were co-stained for BrdU and doublecortin (DCX; new immature neuronal cells) on day 9 or NeuN (new mature neuronal cells) on day 28. On day 9 after sham operation, cell proliferation and neurogenesis occurred in the cortex in rats. The sole induction of CSD had no effect. But on days 9 and 28, more proliferating cells and newly formed neurons in the ipsilateral cortex were observed in rats subjected to CSD + 2VO than in rats subjected to sham operation. On days 9 and 28, cell proliferation and neurogenesis in the ipsilateral dentate gyrus was increased in sham-operated rats than in naïve rats. Our data supports the hypothesis that induced cortical neurogenesis after CSD + 2-VO is a direct effect of ischemia, rather than of CSD alone.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY-NC-SA	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-sa/3.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Spreading depression and focal venous cerebral ischemia enhance cortical neurogenesis	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7132	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Neural regeneration research	de
jgu.journal.volume	12	de
jgu.journal.issue	8	de
jgu.pages.start	1278	de
jgu.pages.end	1286	de
jgu.publisher.year	2017	-
jgu.publisher.name	Wolters Kluwer Health Medknow	de
jgu.publisher.place	Mumbai	de
jgu.publisher.uri	http://dx.doi.org/10.4103/1673-5374.213547	de
jgu.publisher.issn	1673-5374	de
jgu.publisher.issn	1876-7958	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-03-13T11:33:47Z	-
opus.subject.dfgcode	00-000	-
opus.organisation.string	FB 04: Medizin: Institut für Neurochirurgische Pathophysiologie	de_DE
opus.identifier.opusid	57971	-
opus.institute.number	0442	-
opus.metadataonly	false	-
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Alessandri, Beat	-
opus.affiliated	Kempski, Oliver	-
opus.affiliated	Heimann, Axel	-
jgu.publisher.doi	10.4103/1673-5374.213547	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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