Please use this identifier to cite or link to this item:
Authors: Fieß, Achim
Hufschmidt-Merizian, Clara
Gißler, Sandra
Hampel, Ulrike
Mildenberger, Eva
Urschitz, Michael S.
Zepp, Fred
Stoffelns, Bernhard
Pfeiffer, Norbert
Schuster, Alexander K.
Title: Dry eye parameters and lid geometry in adults born extremely, very, and moderately preterm with and without ROP : results from the Gutenberg Prematurity Eye Study
Online publication date: 20-Dec-2022
Year of first publication: 2022
Language: english
Abstract: Background/Aims: This study aimed to analyze the effects of perinatal history on tear film properties and lid geometry in adults born preterm. Methods: The Gutenberg Prematurity Eye Study (GPES) is a German prospective examination of adults born preterm and term aged 18 to 52 years with Keratograph® 5M and Schirmer test I. Main outcome measures were first non-invasive tear film break-up time (F-NITBUT), bulbar redness (BR), Schirmer test, and nasal palpebral angle measurement. The associations with gestational age (GA), birth weight (BW), and BW percentile, retinopathy of prematurity (ROP), ROP treatment, and other perinatal factors were evaluated using regression analyses. Results: 489 eyes of 255 preterm and 277 eyes of 139 full-term individuals (aged 28.6 +/− 8.8 years, 220 females) were included. Of these, 33 participants (56 eyes) had a history of spontaneously regressed ROP and 9 participants (16 eyes) had a history of ROP treatment. After adjustment for age and sex, lower F-NITBUT (<20 s) was associated with ROP treatment (OR = 4.42; p = 0.025). Lower GA correlated with increased bulbar redness (B = −0.02; p = 0.011) and increased length of wetting in the Schirmer test (B = −0.69; p = 0.003). Furthermore, low GA was associated with narrowing of the nasal palpebral angle (B = 0.22; p = 0.011) adjusted for age and sex, but not when considering ROP in the multivariable model. Conclusion: Our analyses indicate that perinatal history affects ocular surface properties, tear production and lid geometry in adults born term and preterm. This might indicate that affected persons have a predisposition to diseases of the corneal surface such as the dry eye disease.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Scientific article
License: CC BY
Information on rights of use:
Journal: Journal of Clinical Medicine
Pages or article number: 2702
Publisher: MDPI
Publisher place: Basel
Issue date: 2022
ISSN: 2077-0383
Publisher URL:
Publisher DOI: 10.3390/jcm11102702
Appears in collections:DFG-491381577-G

Files in This Item:
  File Description SizeFormat
dry_eye_parameters_and_lid_ge-20220524114138644.pdf1.35 MBAdobe PDFView/Open