Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7010
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dc.contributor.authorKellner, Vanessa-
dc.contributor.authorLuke, Brian-
dc.date.accessioned2022-05-20T10:11:25Z-
dc.date.available2022-05-20T10:11:25Z-
dc.date.issued2020-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7024-
dc.description.abstractThe duplication of the eukaryotic genome is an intricate process that has to be tightly safe-guarded. One of the most frequently occurring errors during DNA synthesis is the mis-insertion of a ribonucleotide instead of a deoxyribonucleotide. Ribonucleotide excision repair (RER) is initiated by RNase H2 and results in error-free removal of such mis-incorporated ribonucleotides. If left unrepaired, DNA-embedded ribonucleotides result in a variety of alterations within chromosomal DNA, which ultimately lead to genome instability. Here, we review how genomic ribonucleotides lead to chromosomal aberrations and discuss how the tight regulation of RER timing may be important for preventing unwanted DNA damage. We describe the structural impact of unrepaired ribonucleotides on DNA and chromatin and comment on the potential consequences for cellular fitness. In the context of the molecular mechanisms associated with faulty RER, we have placed an emphasis on how and why increased levels of genomic ribonucleotides are associated with severe autoimmune syndromes, neuropathology, and cancer. In addition, we discuss therapeutic directions that could be followed for pathologies associated with defective removal of ribonucleotides from double-stranded DNA.en_GB
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleMolecular and physiological consequences of faulty eukaryotic ribonucleotide excision repairen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-7010-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 10 Biologiede
jgu.organisation.number7970-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleThe EMBO journalde
jgu.journal.volume39de
jgu.pages.alternativee102309de
jgu.publisher.year2020-
jgu.publisher.nameEMBO Pressde
jgu.publisher.placeHeidelbergde
jgu.publisher.issn1460-2075de
jgu.organisation.placeMainz-
jgu.subject.ddccode570de
jgu.publisher.doi10.15252/embj.2019102309de
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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