Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6507
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWierczeiko, Anna-
dc.contributor.authorGammel, Lena-
dc.contributor.authorRadyushkin, Konstantin-
dc.contributor.authorNguyen, Vu Thu Thuy-
dc.contributor.authorTodorov, Hristo-
dc.contributor.authorGerber, Susanne-
dc.contributor.authorEndres, Kristina-
dc.date.accessioned2021-11-15T09:50:42Z-
dc.date.available2021-11-15T09:50:42Z-
dc.date.issued2021-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/6517-
dc.description.abstractPhysical activity is considered a promising preventive intervention to reduce the risk of developing Alzheimer’s disease (AD). However, the positive effect of therapeutic administration of physical activity has not been proven conclusively yet, likely due to confounding factors such as varying activity regimens and life or disease stages. To examine the impact of different routines of physical activity in the early disease stages, we subjected young 5xFAD and wild-type mice to 1-day (acute) and 30-day (chronic) voluntary wheel running and compared them with age-matched sedentary controls. We observed a significant increase in brain lactate levels in acutely trained 5xFAD mice relative to all other experimental groups. Subsequent brain RNA-seq analysis did not reveal major differences in transcriptomic regulation between training durations in 5xFAD mice. In contrast, acute training yielded substantial gene expression changes in wild-type animals relative to their chronically trained and sedentary counterparts. The comparison of 5xFAD and wild-type mice showed the highest transcriptional differences in the chronic and sedentary groups, whereas acute training was associated with much fewer differentially expressed genes. In conclusion, our results suggest that different training durations did not affect the global transcriptome of 3-month-old 5xFAD mice, whereas acute running seemed to induce a similar transcriptional stress state in wild-type animals as already known for 5xFAD miceen_GB
dc.description.sponsorshipOpen Access-Publizieren Universität Mainz / Universitätsmedizin Mainzde
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleVoluntary wheel running did not alter gene expression in 5xfad mice, but in wild-type animals exclusively after one-day of physical activityen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-6507-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 10 Biologiede
jgu.organisation.number7970-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleCellsde
jgu.journal.volume10de
jgu.journal.issue3de
jgu.pages.alternative693de
jgu.publisher.year2021-
jgu.publisher.nameMDPIde
jgu.publisher.placeBaselde
jgu.publisher.urihttps://doi.org/10.3390/cells10030693de
jgu.publisher.issn2073-4409de
jgu.organisation.placeMainz-
jgu.subject.ddccode570de
jgu.publisher.doi10.3390/cells10030693
Appears in collections:JGU-Publikationen

Files in This Item:
  File Description SizeFormat
Thumbnail
wierczeiko_anna-voluntary_whee-20211115104051151.pdf2.79 MBAdobe PDFView/Open