Gutenberg Open Science: Voluntary wheel running did not alter gene expression in 5xfad mice, but in wild-type animals exclusively after one-day of physical activity

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6507

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DC Field	Value	Language
dc.contributor.author	Wierczeiko, Anna	-
dc.contributor.author	Gammel, Lena	-
dc.contributor.author	Radyushkin, Konstantin	-
dc.contributor.author	Nguyen, Vu Thu Thuy	-
dc.contributor.author	Todorov, Hristo	-
dc.contributor.author	Gerber, Susanne	-
dc.contributor.author	Endres, Kristina	-
dc.date.accessioned	2021-11-15T09:50:42Z	-
dc.date.available	2021-11-15T09:50:42Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6517	-
dc.description.abstract	Physical activity is considered a promising preventive intervention to reduce the risk of developing Alzheimer’s disease (AD). However, the positive effect of therapeutic administration of physical activity has not been proven conclusively yet, likely due to confounding factors such as varying activity regimens and life or disease stages. To examine the impact of different routines of physical activity in the early disease stages, we subjected young 5xFAD and wild-type mice to 1-day (acute) and 30-day (chronic) voluntary wheel running and compared them with age-matched sedentary controls. We observed a significant increase in brain lactate levels in acutely trained 5xFAD mice relative to all other experimental groups. Subsequent brain RNA-seq analysis did not reveal major differences in transcriptomic regulation between training durations in 5xFAD mice. In contrast, acute training yielded substantial gene expression changes in wild-type animals relative to their chronically trained and sedentary counterparts. The comparison of 5xFAD and wild-type mice showed the highest transcriptional differences in the chronic and sedentary groups, whereas acute training was associated with much fewer differentially expressed genes. In conclusion, our results suggest that different training durations did not affect the global transcriptome of 3-month-old 5xFAD mice, whereas acute running seemed to induce a similar transcriptional stress state in wild-type animals as already known for 5xFAD mice	en_GB
dc.description.sponsorship	Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	Voluntary wheel running did not alter gene expression in 5xfad mice, but in wild-type animals exclusively after one-day of physical activity	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6507	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Cells	de
jgu.journal.volume	10	de
jgu.journal.issue	3	de
jgu.pages.alternative	693	de
jgu.publisher.year	2021	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	https://doi.org/10.3390/cells10030693	de
jgu.publisher.issn	2073-4409	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
jgu.publisher.doi	10.3390/cells10030693
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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