Authors:	Payne, Emily Sarah
Title:	In vitro-Testung eines Kathetermodells mit einer trichterförmig erweiterten Spitze zur Reduktion von Thrombusmigration unter Verwendung von verschiedenen Thrombuskompositionen für die mechanische Thrombektomie In vitro Testing of a Funnel-tip Catheter Model to Decrease Clot Migration and to Evaluate Clot Effects in Mechanical Thrombectomy
Online publication date:	12-Jan-2022
Year of first publication:	2022
Language:	english
Abstract:	Clot-retrieval failure and embolism in new territories (ENT) are complications reducing the ecacy ofmechanical thrombectomy (MT). Reasons for these problems are clot abruption during stent retrieverretraction into the cylindrical tip of a standard distal access catheter (DAC), and antegrade blood owduring retrieval. To overcome these complications, a funnel-shaped tip catheter model was developed andtested. Using an experimental in vitro setup, this study compared the ecacy of a funnel-shaped tip witha standard cylindrical tip in combination with different clot compositions. Mechanical thrombectomy wasperformed 80 times for each tip, using two stent retrievers (Trevo XP ProVue 3/20 mm and 4/20 mm) andfour different clot types (mechanical vs. static preparation, 0-24h vs. 72h clot aging times). Signicantlyhigher rst-pass recanalization rates were observed for the funnel-shaped tip, which reached 70.0% vs.30.0% for the standard tip (absolute difference, 32; relative difference 20.0%, P < 0.05), regardless of theclot type and stent retriever. Recanalization could be increased using brin-rich mechanical clots vs. clotsprepared under static conditions, as well as 0-24h vs. 72h aged clots, respectively. The extended in vitro-experiments veried the usability of the recently patented funnel-shaped DAC, hereby implementing next-level in vivo-experiments.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6465
URN:	urn:nbn:de:hebis:77-openscience-c1875880-959f-4c22-9980-6d3ad4debf461
Version:	Original work
Publication type:	Dissertation
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Extent:	110 Seiten, Illustrationen
Publisher:	Research Square Preprint Version (not published yet)
Issue date:	2021
Publisher URL:	https://www.researchgate.net/publication/349418192_In_vitro_testing_of_a_funnel-tip_catheter_model_to_decrease_clot_migration_and_to_evaluate_clot_effects_in_mechanical_thrombectomy
Appears in collections:	JGU-Publikationen