Gutenberg Open Science: Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6354

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DC Field	Value	Language
dc.contributor.author	Rosales Jubal, Eduardo	-
dc.contributor.author	Schwalm, Miriam	-
dc.contributor.author	Santos Guilherme, Malena dos	-
dc.contributor.author	Schuck, Florian	-
dc.contributor.author	Reinhardt, Sven	-
dc.contributor.author	Tose, Amanda	-
dc.contributor.author	Barger, Zeke	-
dc.contributor.author	Roesler, Mona K.	-
dc.contributor.author	Ruffini, Nicolas	-
dc.contributor.author	Wierczeiko, Anna	-
dc.contributor.author	Schmeisser, Michael J.	-
dc.contributor.author	Schmitt, Ulrich	-
dc.contributor.author	Endres, Kristina	-
dc.contributor.author	Stroh, Albrecht	-
dc.date.accessioned	2021-09-20T09:08:32Z	-
dc.date.available	2021-09-20T09:08:32Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6364	-
dc.description.abstract	Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed in microcircuits of mice AD-models showing plaques, and also recently in early stage AD mutants prior to amyloid deposition. However, early functional effects of AD on cortical microcircuits remain unresolved. Using two-photon calcium imaging, we found altered temporal distributions (burstiness) in the spontaneous activity of layer II/III visual cortex neurons, in a mouse model of familial Alzheimer’s disease (5xFAD), before plaque formation. Graph theory (GT) measures revealed a distinct network topology of 5xFAD microcircuits, as compared to healthy controls, suggesting degradation of parameters related to network robustness. After treatment with acitretin, we observed a re-balancing of those network measures in 5xFAD mice; particularly in the mean degree distribution, related to network development and resilience, and post-treatment values resembled those of age-matched controls. Further, behavioral deficits, and the increase of excitatory synapse numbers in layer II/III were reversed after treatment. GT is widely applied for whole-brain network analysis in human neuroimaging, we here demonstrate the translational value of GT as a multi-level tool, to probe networks at different levels in order to assess treatments, explore mechanisms, and contribute to early diagnosis.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Acitretin reverses early functional network degradation in a mouse model of familial Alzheimer’s disease	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6354	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Scientific reports	de
jgu.journal.volume	11	de
jgu.pages.alternative	6649	de
jgu.publisher.year	2021	-
jgu.publisher.name	Macmillan Publishers Limited, part of Springer Nature	de
jgu.publisher.place	London	de
jgu.publisher.uri	https://doi.org/10.1038/s41598-021-85912-0	de
jgu.publisher.issn	2045-2322	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1038/s41598-021-85912-0	-
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	JGU-Publikationen

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