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Autoren: Zhou, Yawen
Li, Huige
Xia, Ning
Titel: The interplay between adipose tissue and vasculature : role of oxidative stress in obesity
Online-Publikationsdatum: 2-Aug-2021
Sprache des Dokuments: Englisch
Zusammenfassung/Abstract: Cardiovascular diseases (CVDs) rank the leading cause of morbidity and mortality globally. Obesity and its related metabolic syndrome are well-established risk factors for CVDs. Therefore, understanding the pathophysiological role of adipose tissues is of great importance in maintaining cardiovascular health. Oxidative stress, characterized by excessive formation of reactive oxygen species, is a common cellular stress shared by obesity and CVDs. While plenty of literatures have illustrated the vascular oxidative stress, very few have discussed the impact of oxidative stress in adipose tissues. Adipose tissues can communicate with vascular systems, in an endocrine and paracrine manner, through secreting several adipocytokines, which is largely dysregulated in obesity. The aim of this review is to summarize current understanding of the relationship between oxidative stress in obesity and vascular endothelial dysfunction. In this review, we briefly describe the possible causes of oxidative stress in obesity, and the impact of obesity-induced oxidative stress on adipose tissue function. We also summarize the crosstalk between adipose tissue and vasculature mediated by adipocytokines in vascular oxidative stress. In addition, we highlight the potential target mediating adipose tissue oxidative stress.
DDC-Sachgruppe: 610 Medizin
610 Medical sciences
Veröffentlichende Institution: Johannes Gutenberg-Universität Mainz
Organisationseinheit: FB 04 Medizin
Veröffentlichungsort: Mainz
Version: Published version
Publikationstyp: Zeitschriftenaufsatz
Nutzungsrechte: CC BY
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Zeitschrift: Frontiers in Cardiovascular Medicine
Seitenzahl oder Artikelnummer: 650214
Verlag: Frontiers Media
Verlagsort: Lausanne
Erscheinungsdatum: 2021
ISSN: 2297-055X
URL der Originalveröffentlichung:
DOI der Originalveröffentlichung: 10.3389/fcvm.2021.650214
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