Autoren:	Röckl, Johannes L. Dörr, Maurice Waldvogel, Siegfried R.
Titel:	Electrosynthesis 2.0 in 1,1,1,3,3,3-hexafluoroisopropanol/amine mixtures
Online-Publikationsdatum:	6-Jul-2021
Erscheinungsdatum:	2020
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	The intention of this review is to highlight the innovative electrolyte combination of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) with tertiary nitrogen bases in electro-organic synthesis. This easy applicable and promising mixture is not yet well established in electro-organic synthesis, but expands the various possibilities in the latter. Combinations of fluorinated alcohols with nitrogen bases form highly conductive electrolyte systems, which can be evaporated completely. Consequently, no additional supporting electrolyte is required and work-up procedures are tremendously simplified. With this electrolyte mixture carbon-carbon homo- and cross-coupling reactions of arenes and phenols have been established with substrates that have not been previously susceptible to the anodic dehydrogenative coupling reaction. The intermediate installation of highly fluorinated alkoxy moieties can be exploited for subsequent conversions as well as various benzylic functionalization, including asymmetric transformations. These transformations show unique selectivity and functional group tolerance making them highly applicable to the synthesis of sophisticated structural motifs, including natural products.
DDC-Sachgruppe:	540 Chemie 540 Chemistry and allied sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 09 Chemie, Pharmazie u. Geowissensch.
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6181
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY-NC-ND
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by-nc-nd/4.0/
Zeitschrift:	ChemElectroChem 7 18
Seitenzahl oder Artikelnummer:	3686 3694
Verlag:	Wiley-VCH
Verlagsort:	Weinheim
Erscheinungsdatum:	2020
ISSN:	2196-0216
URL der Originalveröffentlichung:	https://doi.org/10.1002/celc.202000761
DOI der Originalveröffentlichung:	10.1002/celc.202000761
Enthalten in den Sammlungen:	JGU-Publikationen