Gutenberg Open Science: Non-pharmacologic multicomponent interventions preventing delirium in hospitalized people

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6172

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DC Field	Value	Language
dc.contributor.author	Ludolph, Paul	-
dc.contributor.author	Stoffers-Winterling, Jutta	-
dc.contributor.author	Kunzler, Angela M.	-
dc.contributor.author	Rösch, Romina	-
dc.contributor.author	Geschke, Katharina	-
dc.contributor.author	Vahl, Christian Friedrich	-
dc.contributor.author	Lieb, Klaus	-
dc.date.accessioned	2021-07-05T10:01:47Z	-
dc.date.available	2021-07-05T10:01:47Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6181	-
dc.description.abstract	BACKGROUND/OBJECTIVES Delirium is a common neurobehavioral complication in hospitalized patients with a high prevalence in various clinical settings. Prevention of delirium is critical due to its common occurrence and associated poor outcomes. Our objective was to evaluate the efficacy of multicomponent interventions in preventing incident delirium in hospitalized patients at risk. DESIGN Systematic review and meta-analysis. SETTING Hospital. PARTICIPANTS We included a study if it was a randomized controlled trial and was evaluating effects of coordinated non-pharmacologic multicomponent interventions in the prevention of delirium. MEASUREMENTS We performed a systematic literature search in PubMed and CENTRAL (PROSPERO: CRD42019138981; last update May 24, 2019). We assessed the quality of included studies by using the criteria established by the Cochrane Collaboration. We extracted the measured outcomes for delirium incidence, duration of delirium, length of hospital stay, falls during hospital stay, discharge to institutional care, and inpatient mortality. RESULTS In total, we screened 1,027 eligible records and included eight studies with 2,105 patients in the review. We found evidence of an effect (ie, reduction) of multicomponent interventions on the incidence of delirium (risk ratio = .53; 95% confidence interval = .41-.69; I2 = 0). We detected no clear evidence of an effect for delirium duration, length of hospital stay, accidental falls, and mortality. Subgroup analyses did not result in findings of substantial effect modifiers, which can be explained by the high homogeneity within studies. CONCLUSION Our findings confirm the current guidelines that multicomponent interventions are effective in preventing delirium. Data are still lacking to reach evidence-based conclusions concerning potential benefits for hard outcomes such as length of hospital stay, return to independent living, and mortality. J Am Geriatr Soc 68:1864-1871, 2020.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC-ND	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Non-pharmacologic multicomponent interventions preventing delirium in hospitalized people	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6172	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Journal of the American Geriatrics Society	de
jgu.journal.volume	68	de
jgu.journal.issue	8	de
jgu.pages.start	1864	de
jgu.pages.end	1871	de
jgu.publisher.year	2020	-
jgu.publisher.name	Wiley-Blackwell	de
jgu.publisher.place	Oxford u.a.	de
jgu.publisher.uri	https://doi.org/10.1111/jgs.16565	de
jgu.publisher.issn	1532-5415	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/jgs.16565
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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