Gutenberg Open Science: The use of the macrocyclic chelator DOTA in radiochemical separations

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6095

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DC Field	Value	Language
dc.contributor.author	Baranyai, Zsolt	-
dc.contributor.author	Tircsó, Gyula	-
dc.contributor.author	Rösch, Frank	-
dc.date.accessioned	2021-06-28T09:57:46Z	-
dc.date.available	2021-06-28T09:57:46Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6104	-
dc.description.abstract	Radiometals play an important role in the diagnosis of physiological processes in vivo by means of imaging technologies, but also increasingly contribute to the treatment of diseases. The by far dominant way to apply the advantages of nuclear transformations of radiometals is the use of radiometal-ligand complexes. In this context, it turns out that DOTA (and its derivatives) currently is the most potent chelator. This article reviews the physico-chemical properties of DOTA and its [M(DOTA)]– complexes, which made the DOTA moiety the dominant chelator for theranostics in radiopharmaceutical chemistry and nuclear medicine. Interestingly, and beyond nuclear medicine applications, the physico-chemical properties of [M(DOTA)] complexes open access to unique radiochemical separation strategies, which for decades appeared to be impossible not only within conventional chemistry, but also within modern radiochemistry. We will discuss three groups of such separations: i) the radiochemical separation of two chemically very similar elements such as two neighbor lanthanides, ii) the radiochemical separation of two isotopes of the same element, and even iii) the radiochemical separation of two nuclear levels of one and the same isotope.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	540 Chemie	de_DE
dc.subject.ddc	540 Chemistry and allied sciences	en_GB
dc.title	The use of the macrocyclic chelator DOTA in radiochemical separations	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6095	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 09 Chemie, Pharmazie u. Geowissensch.	de
jgu.organisation.number	7950	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	European journal of inorganic chemistry	de
jgu.journal.volume	2020	de
jgu.journal.issue	1	de
jgu.pages.start	36	de
jgu.pages.end	56	de
jgu.publisher.year	2020	-
jgu.publisher.name	Wiley-VCH	de
jgu.publisher.place	Weinheim	de
jgu.publisher.uri	https://doi.org/10.1002/ejic.201900706	de
jgu.publisher.issn	1099-0682	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	540	de
jgu.publisher.doi	10.1002/ejic.201900706
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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