Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6095
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dc.contributor.authorBaranyai, Zsolt-
dc.contributor.authorTircsó, Gyula-
dc.contributor.authorRösch, Frank-
dc.date.accessioned2021-06-28T09:57:46Z-
dc.date.available2021-06-28T09:57:46Z-
dc.date.issued2020-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/6104-
dc.description.abstractRadiometals play an important role in the diagnosis of physiological processes in vivo by means of imaging technologies, but also increasingly contribute to the treatment of diseases. The by far dominant way to apply the advantages of nuclear transformations of radiometals is the use of radiometal-ligand complexes. In this context, it turns out that DOTA (and its derivatives) currently is the most potent chelator. This article reviews the physico-chemical properties of DOTA and its [*M(DOTA)]– complexes, which made the DOTA moiety the dominant chelator for theranostics in radiopharmaceutical chemistry and nuclear medicine. Interestingly, and beyond nuclear medicine applications, the physico-chemical properties of [*M(DOTA)] complexes open access to unique radiochemical separation strategies, which for decades appeared to be impossible not only within conventional chemistry, but also within modern radiochemistry. We will discuss three groups of such separations: i) the radiochemical separation of two chemically very similar elements such as two neighbor lanthanides, ii) the radiochemical separation of two isotopes of the same element, and even iii) the radiochemical separation of two nuclear levels of one and the same isotope.en_GB
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc540 Chemiede_DE
dc.subject.ddc540 Chemistry and allied sciencesen_GB
dc.titleThe use of the macrocyclic chelator DOTA in radiochemical separationsen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-6095-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.de
jgu.organisation.number7950-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleEuropean journal of inorganic chemistryde
jgu.journal.volume2020de
jgu.journal.issue1de
jgu.pages.start36de
jgu.pages.end56de
jgu.publisher.year2020-
jgu.publisher.nameWiley-VCHde
jgu.publisher.placeWeinheimde
jgu.publisher.urihttps://doi.org/10.1002/ejic.201900706de
jgu.publisher.issn1099-0682de
jgu.organisation.placeMainz-
jgu.subject.ddccode540de
jgu.publisher.doi10.1002/ejic.201900706
Appears in collections:JGU-Publikationen

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